ArticleRedox biology2017
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Open access · goldAbstract read
In one paragraph
Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review.Cellular and molecular gastroenterology and hepatology · 2021Pooled it
- Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region.EBioMedicine · 2024Article
- Selenium, Immunity, and Inflammatory Bowel Disease.Nutrients · 2024Review
- Evaluation of the Use of Cell Lines in Studies of Selenium-Dependent Glutathione Peroxidase 2 (GPX2) Involvement in Colorectal Cancer.Diseases (Basel, Switzerland) · 2024Article
- Article
- The beginning of GPX2 and 30 years later.Free radical biology & medicine · 2022Review
- Roscovitine WorsensAmerican journal of respiratory cell and molecular biology · 2022Article
- Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases.Biomedicines · 2022Review
- Telomere dysfunction instigates inflammation in inflammatory bowel disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.Carcinogenesis · 2021Article
- Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease-Glutathione peroxide isoenzymes 1 and 2-double knockout mice on a C57BL background.MicrobiologyOpen · 2020Article
- Review
- Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms.Redox biology · 2020Article
- Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2.Life sciences · 2019Article
- IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.Mucosal immunology · 2019Article
- Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing HFrontiers in physiology · 2019Article
- Selenoproteins in colon cancer.Free radical biology & medicine · 2018Review
- Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease.JCI insight · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Fong-Fong ChuDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, China; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, 1450 E Duarte Road, Duarte, CA 91010, USA. Electronic address: fchu@coh.org.
R Steven EsworthyDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
James H DoroshowCenter for Cancer Research and Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA.
Helmut GrasbergerDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Agnes DonkoNational Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Thomas L LetoNational Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Qiang GaoDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, China.
Binghui ShenDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Beckman Research InstituteNational Institute of Allergy and Infectious Diseases · USCity of Hope · USFirst Affiliated Hospital of Henan University of Science and Technology · CNNational Cancer Institute · USUniversity of Michigan–Ann Arbor · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MNOX family NADPH oxidases: roles in innate immunity and inflammatory diseaseZIAAI000614 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LETO, THOMAS · 2009 to 2024
$16.2MNADPH Oxidases as Novel Targets for Cancer TherapyZIABC010677 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES · 2009 to 2025
$15.1MRole of Nucleases in RNA Primer Removal and MutagenesisR01CA085344 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI SHEN, BINGHUI · 1999 to 2024
$7.7MThe role of glutathione peroxidase in the pathogenesis of intestinal cancerR01CA114569 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHU, FONG-FONG · 2006 to 2010
$1.4MNCI NIH HHS P30 CA033572NCI NIH HHS R01 CA085344NCI NIH HHS R01 CA114569
Abstract
Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1
Indexed as
AnimalsApoptosisColonDual OxidasesGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansIleitisInflammationInflammatory Bowel DiseasesMiceMice, KnockoutNADPH Oxidase 1Onium CompoundsOxidation-ReductionReactive Oxygen SpeciesDual OxidasesDuox2 protein, mouseGlutathione PeroxidaseGlutathione Peroxidase GPX1Gpx2 protein, mouseiodonium thiopheneNADPH Oxidase 1NOX1 protein, mouseOnium CompoundsReactive Oxygen SpeciesThiophenesDouble-knockout mouseDual oxidase-2Glutathione peroxidaseNADPH oxidaseVery-early-onset inflammatory-bowel-disease
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.