Evidence map›Paper›PMID 27930899›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2017

The cingulate cortex of older adults with excellent memory capacity.

Feng Lin, Ping Ren, Mark Mapstone, Steven P Meyers, Anton Porsteinsson, Timothy M Baran, Alzheimer's Disease Neuroimaging Initiative

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  18. Aging and the encoding of changes in events: The role of neural activity pattern reinstatement.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Feng LinSchool of Nursing, University of Rochester Medical Center, United States; Department of Psychiatry, School of Medicine and Dentistry, University of Rochester Medical Center, United States; Department of Brain and Cognitive Science, University of Rochester, United States. Electronic address: Vankee_lin@urmc.rochester.edu.
Ping RenSchool of Nursing, University of Rochester Medical Center, United States.
Mark MapstoneDepartment of Neurology, University of California-Irvine, United States.
Steven P MeyersDepartment of Imaging Sciences, University of Rochester Medical Center, United States.
Anton PorsteinssonDepartment of Psychiatry, School of Medicine and Dentistry, University of Rochester Medical Center, United States.
Timothy M BaranDepartment of Imaging Sciences, University of Rochester Medical Center, United States.
Alzheimer's Disease Neuroimaging Initiative
University of Rochester Medical Center · USUniversity of California, Irvine · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive ImpairmentR01NR015452 · NINR · UNIVERSITY OF ROCHESTER · PI HEFFNER, KATHI L, LIN, FENG VANKEE · 2015 to 2024
$4.4M
CIHRNIA NIH HHS U01 AG024904NINR NIH HHS R01 NR015452
6 · The paper itself

Abstract

Memory deterioration is the earliest and most devastating cognitive deficit in normal aging and Alzheimer's disease (AD). Some older adults, known as "Supernormals", maintain excellent memory. This study examined relationships between cerebral amyloid deposition and functional connectivity (FC) within the cingulate cortex (CC) and between CC and other regions involved in memory maintenance between Supernormals, healthy controls (HC), and those at risk for AD (amnestic mild cognitive impairment [MCI]). Supernormals had significantly stronger FC between anterior CC and R-hippocampus, middle CC (MCC) and L-superior temporal gyrus, and posterior CC (PCC) and R-precuneus, while weaker FC between MCC and R-middle frontal gyrus and MCC and R-thalamus than other groups. All of these FC were significantly related to memory and global cognition in all participants. Supernormals had less amyloid deposition than other groups. Relationships between global cognition and FC were stronger among amyloid positive participants. Relationships between memory and FC remained regardless of amyloid level. This revealed how CC-related neural function participates in cognitive maintenance in the presence of amyloid deposition, potentially explaining excellent cognitive function among Supernormals.

Indexed as

AgedAged, 80 and overAmnesiaCognitionCognitive DysfunctionFemaleGyrus CinguliHumansMaleMemoryNerve NetNeuropsychological TestsCerebral amyloid depositionCingulate cortexFunctional connectivityMemorySupernormal

Identifiers

PMID27930899
PMCPMC5253250
OpenAlexW2554781005

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.