Evidence map›Paper›PMID 27930880›Full record

ArticleACS applied materials & interfaces2016

Micropatterned Polymer Nanorod Forests and Their Use for Dual Drug Loading and Regulation of Cell Adhesion.

Chunlei Zhu, Jiajia Xue, Kyle D Gilroy, Da Huo, Song Shen, Younan Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunlei ZhuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.ORCID http://orcid.org/0000-0003-2477-306X
Jiajia XueThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
Kyle D GilroyThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.ORCID http://orcid.org/0000-0002-3153-8060
Da HuoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
Song ShenThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
Younan XiaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.ORCID http://orcid.org/0000-0003-2431-7048

Funding

Nanofiber Scaffolds with Gradations in Mineral Content for Rotator Cuff RepairR01AR060820 · NIAMS · WASHINGTON UNIVERSITY · PI GALATZ, LEESA M, THOMOPOULOS, STAVROS · 2011 to 2015
$2.2M
NIAMS NIH HHS R01 AR060820
6 · The paper itself

Abstract

This paper describes a simple method for the fabrication of micropatterned polymer nanorod forests by templating against the channels in an anodized aluminum oxide membrane partially masked by gelatin. The nanorod forests easily support bimodal drug loading, with one drug encapsulated in the nanorods and the other physisorbed on their surface. During cell culture, preosteoblasts are predominantly attracted to the nanorod forests and driven to climb up along the nanorods. This type of scaffold integrates both microscale and nanoscale features into a single substrate, holding great potential for applications in cell culture and tissue engineering.

Indexed as

3T3 CellsAluminum OxideAnimalsCell AdhesionDrug Delivery SystemsGelatinLactic AcidMiceNanotubesOsteoblastsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTissue EngineeringAluminum OxideGelatinLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymercell adhesiondual drug loadingmicropatterningnanorod foreststissue engineering

Identifiers

PMID27930880
PMCPMC6625765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.