ArticleChembiochem : a European journal of chemical biology2017
Brominated Luciferins Are Versatile Bioluminescent Probes.
Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools.Chembiochem : a European journal of chemical biology · 2023Article
- Multiplexed bioluminescence imaging with a substrate unmixing platform.Cell chemical biology · 2022Article
- Computational Investigation of Substituent Effects on the Fluorescence Wavelengths of Oxyluciferin Analogs.Journal of photochemistry and photobiology. A, Chemistry · 2022Article
- Multiplexed bioluminescence microscopy via phasor analysis.Nature methods · 2022Article
- Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores through Convergent Synthesis.Angewandte Chemie (International ed. in English) · 2022Article
- Systematic Comparison of Beetle Luciferase-Luciferin Pairs as Sources of Near-Infrared Light for In Vitro and In Vivo Applications.International journal of molecular sciences · 2022Article
- Rapid Multicomponent Bioluminescence ImagingACS chemical biology · 2021Article
- Molecular Design of d-Luciferin-Based Bioluminescence and 1,2-Dioxetane-Based Chemiluminescence Substrates for Altered Output Wavelength and Detecting Various Molecules.Molecules (Basel, Switzerland) · 2021Review
- Orthogonal Bioluminescent Probes from Disubstituted Luciferins.Biochemistry · 2021Article
- Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology.Cell chemical biology · 2020Review
- Building Biological Flashlights: Orthogonal Luciferases and Luciferins forAccounts of chemical research · 2019Review
- Computational investigation into the fluorescence of luciferin analogues.Journal of computational chemistry · 2019Article
- Lessons Learned from Luminous Luciferins and Latent Luciferases.ACS chemical biology · 2018Review
- Pyridone Luciferins and Mutant Luciferases for Bioluminescence Imaging.Chembiochem : a European journal of chemical biology · 2018Article
- Statistical Coupling Analysis-Guided Library Design for the Discovery of Mutant Luciferases.Biochemistry · 2018Article
- Parallel Screening for Rapid Identification of Orthogonal Bioluminescent Tools.ACS central science · 2017Article
- Rapid Access to a Broad Range of 6'-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors.Organic letters · 2017Article
- Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes.ACS central science · 2017Article
- Orthogonal Luciferase-Luciferin Pairs for Bioluminescence Imaging.Journal of the American Chemical Society · 2017Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
We report a set of brominated luciferins for bioluminescence imaging. These regioisomeric scaffolds were accessed by using a common synthetic route. All analogues produced light with firefly luciferase, although varying levels of emission were observed. Differences in photon output were analyzed by computation and photophysical measurements. The brightest brominated luciferin was further evaluated in cell and animal models. At low doses, the analogue outperformed the native substrate in cells. The remaining luciferins, although weak emitters with firefly luciferase, were inherently capable of light production and thus potential substrates for orthogonal mutant enzymes.
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