Observational studyMedicine2016
Low mortality but increasing incidence of Staphylococcus aureus endocarditis in people who inject drugs: Experience from a Swedish referral hospital.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Valve involvement in infective endocarditis among intravenous drug users: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Long term surgical outcomes for infective endocarditis in people who inject drugs: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Article
- Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012).Infectious diseases and therapy · 2023Article
- Epidemiologic and clinical characteristics of infective endocarditis: a single-center retrospective study in the Bronx, New York.Infection · 2022Article
- Infective Endocarditis in People Who Inject Drugs: Report from the Italian Registry of Infective Endocarditis.Journal of clinical medicine · 2022Article
- Article
- Comparing right- and left sided injection-drug related infective endocarditis.Scientific reports · 2021Article
- Computational insight into the protective mechanism ofIn silico pharmacology · 2021Article
- Article
- Three Separate Clinical Entities of Infective Endocarditis-A Population-Based Study From Southern Finland 2013-2017.Open forum infectious diseases · 2020Article
- Contemporary Trends in Native Valve Infective Endocarditis in United States (from the National Inpatient Sample Database).The American journal of cardiology · 2020Article
- Associations between echocardiographic manifestations and bacterial species in patients with infective endocarditis: a cohort study.BMC infectious diseases · 2019Article
- A changing profile of infective endocarditis at a tertiary hospital in China: a retrospective study from 2001 to 2018.BMC infectious diseases · 2019Article
- Reducing injection intensity is associated with decreased risk for invasive bacterial infection among high-frequency injection drug users.Harm reduction journal · 2019Article
- The risk of infective endocarditis among people who inject drugs: a retrospective, population-based time series analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
- Seroprevalence of Bartonella spp., Coxiella burnetii, and Hantavirus among people who inject drugs in Rio de Janeiro, Brazil: a retrospective assessment of a biobank.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- The Changing Epidemiology of Infective Endocarditis in the Twenty-First Century.Current infectious disease reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is a leading cause of infective endocarditis in people who inject drugs (PWID). The management of S aureus endocarditis (SAE) in PWID can be problematic. The objective of this retrospective observational study was to assess the epidemiology, clinical characteristics, and mortality of S aureus endocarditis (SAE) in PWID in Stockholm, Sweden.The Department of Infectious Diseases at the Karolinska University Hospital serves as a regional referral center for drug users with severe infections. Patients with active intravenous drug use treated for SAE at the department between January 2004 and December 2013 were retrospectively identified. Clinical and microbiological data were obtained from medical records and the diagnosis verified according to the modified Duke criteria.In total, 120 SAE episodes related to intravenous drug use were identified. Its incidence in Stockholm was 0.76/100,000 adult person-years for the entire period, increasing from 0.52/100,000 person-years in 2004 to 2008 to 0.99 in 2009 to 2013 (P = 0.02). The SAE incidence among PWID specifically was 249 (range 153-649) /100,000 person-years. Forty-two (35%) episodes were left-sided, and multiple valves were involved in 26 (22%). Cardiac valve surgery was performed in 10 (8%) episodes, all left-sided. The in-hospital and 1-year mortality rates were 2.5% (3 deaths) and 8.0% (9 deaths), respectively.We noted a high and increasing incidence over time of SAE related to intravenous drug use in Stockholm. The increased incidence partly reflects a rising number of PWID during the study period. The low mortality noted, despite a substantial proportion with left-sided endocarditis, probably in part reflects the quality of care obtained at a large and specialized referral center for drug users with severe infections.
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