ArticleProceedings of the National Academy of Sciences of the United States of America2016
Janus effect of antifreeze proteins on ice nucleation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed.
- Rational engineering of an antifreeze-based biomaterial with dual-enhanced ice-binding and delivery for high-efficiency cryopreservation.Journal of advanced research · 2026Article
- Inhibition of Ice Recrystallization by Regulating the Surface Free Energy of Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Bio-based trifunctional integration strategies for aquatic products during frozen storage: Synergistic mechanisms and perspectives.Food chemistry: X · 2026Review
- Design Principles for β-Solenoid Stability via Covalent and Electrostatic Capping Motifs.The journal of physical chemistry letters · 2026Article
- Tunable icephobicity of surface-grown metal-organic frameworks with nanohierarchical texture.Nanoscale · 2026Article
- Concurrent Formation of Ice Network within Mineral Colloids with Suppressed Volume Expansion.The journal of physical chemistry letters · 2026Article
- Cold Shock Protein B as an Alternative to DMSO for Oocyte Vitrification.Antioxidants (Basel, Switzerland) · 2026Article
- An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Research progress on novel bionic cryoprotectants in gamete and embryo cryopreservation.Frontiers in veterinary science · 2026Review
- The mechanism and protective strategies of follicle injury after ovarian tissue cryopreservation and thawed transplantation: a review.Journal of ovarian research · 2025Review
- Characterization of DnaJ gene family in Castanea mollissima and functional analysis of CmDnaJ27 under cold and heat stresses.BMC plant biology · 2025Article
- Identification of ice-binding proteins from Raphanus sativus and application in frozen dough.NPJ science of food · 2025Article
- Condensate Halos in Condensation Frosting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Overcoming ice: cutting-edge materials and advanced strategies for effective cryopreservation of biosample.Journal of nanobiotechnology · 2025Review
- Fully Atomistic Molecular Dynamics Simulation of Ice Nucleation Near an Antifreeze Protein.Journal of the American Chemical Society · 2025Article
- On-demand imidazolidinyl urea-based tissue-like, self-healable, and antibacterial hydrogels for infectious wound care.Bioactive materials · 2025Article
- Boosting the oxygen reduction activity on metal surfaces by fine-tuning interfacial water with midinfrared stimulation.Innovation (Cambridge (Mass.)) · 2025Article
- Relevance of Microorganisms in Causing Rain and Snow.Recent patents on biotechnology · 2025Review
- The Effect of Ice-Binding Protein fromFoods (Basel, Switzerland) · 2024Article
- Scalable robust photothermal superhydrophobic coatings for efficient anti-icing and de-icing in simulated/real environments.Nature communications · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of ice nucleation at the molecular level remains largely unknown. Nature endows antifreeze proteins (AFPs) with the unique capability of controlling ice formation. However, the effect of AFPs on ice nucleation has been under debate. Here we report the observation of both depression and promotion effects of AFPs on ice nucleation via selectively binding the ice-binding face (IBF) and the non-ice-binding face (NIBF) of AFPs to solid substrates. Freezing temperature and delay time assays show that ice nucleation is depressed with the NIBF exposed to liquid water, whereas ice nucleation is facilitated with the IBF exposed to liquid water. The generality of this Janus effect is verified by investigating three representative AFPs. Molecular dynamics simulation analysis shows that the Janus effect can be established by the distinct structures of the hydration layer around IBF and NIBF. Our work greatly enhances the understanding of the mechanism of AFPs at the molecular level and brings insights to the fundamentals of heterogeneous ice nucleation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.