ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Polysubstance Prevalence Estimates Reported during Pregnancy, US, 2009-2020.Maternal and child health journal · 2023Pooled it
- Unveiling social determinants of health impact on adverse pregnancy outcomes through natural language processing.Scientific reports · 2025Article
- A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024Article
- Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth.Pediatric research · 2021Article
- Maternal anemia and pregnancy outcomes: a population-based study.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveExamine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated α-fetoprotein (AFP). STUDY
designThe sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.
resultsWe identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ⩾95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ⩾95th percentile were 11 to 35 times as likely to deliver <32 weeks.
conclusionThe combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.
Indexed as
Identifiers
27929528What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.