ReviewGenetics in medicine : official journal of the American College of Medical Genetics2017
The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues.
Review in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Financing and Reimbursement Models for Personalised Medicine: A Systematic Review to Identify Current Models and Future Options.Applied health economics and health policy · 2022Pooled it
- Are We There Yet? Human Factors Knowledge and Health Information Technology - the Challenges of Implementation and Impact.Yearbook of medical informatics · 2017Pooled it
- The MAPme Project: Implementing a College-Based Study of Substance Use and Mental Wellness.International journal of environmental research and public health · 2026Article
- Harnessing genomic and bioinformatics for surveillance of pathogens in Africa: a scoping review of existing training and gaps in training.BMC infectious diseases · 2026Article
- Predicting incident type 2 diabetes using wearable activity and polygenic risk: A survival-modeling study in All of Us.The Journal of clinical endocrinology and metabolism · 2026Article
- Metabolomics and Human Health: Progress, Insights, Challenges and the Concept of a Healthy Metabolome.Biomolecules · 2026Review
- Sorting out and navigating uncertainty in precision medicine.History and philosophy of the life sciences · 2026Article
- Designing a Digital Twin for the Management of Noncommunicable Diseases: Protocol for a Pilot Study and Methodology Validation.JMIR research protocols · 2026Article
- Health outcomes after national acute sleep deprivation events among the American public.JCI insight · 2026Article
- Returning value to communities from the All of Us Research Program through the lens of social determinants of health and ethical, legal, and social implications.International journal for equity in health · 2026Review
- GPCR systems coordinate cellular resilience against aging-associated stress.Frontiers in molecular biosciences · 2026Review
- Integration of modern technologies to advance dietary assessment.Nature food · 2026Review
- Personalized medicine and health equity: overcoming cost barriers and ethical challenges.International journal for equity in health · 2025Review
- Unveiling the Disparities in the Field of Precision Medicine: A Perspective.Health science reports · 2025Article
- Identification of Transgender and Gender-Diverse Individuals in the All of Us Research Program, 2017-2022.American journal of public health · 2025Article
- Computational strategic recruitment for representation and coverage studied in the All of Us Research Program.NPJ digital medicine · 2025Article
- Sociodemographically differential patterns of chronic pain progression revealed by analyzing the all of us research program data.PLOS digital health · 2025Article
- Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice.Clinical science (London, England : 1979) · 2025Article
- Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.International journal of molecular sciences · 2025Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Precision Medicine Initiative (PMI) is an innovative approach to developing a new model of health care that takes into account individual differences in people's genes, environments, and lifestyles. A cornerstone of the initiative is the PMI All of Us Research Program (formerly known as PMI-Cohort Program) which will create a cohort of 1 million volunteers who will contribute their health data and biospecimens to a centralized national database to support precision medicine research. The PMI All of US Research Program is the largest longitudinal study in the history of the United States. The designers of the Program anticipated and addressed some of the ethical, legal, and social issues (ELSI) associated with the initiative. To date, however, there is no plan to call for research regarding ELSI associated with the Program-PMI All of Us program. Based on analysis of National Institutes of Health (NIH) funding announcements for the PMI All of Us program, we have identified three ELSI themes: cohort diversity and health disparities, participant engagement, and privacy and security. We review All of Us Research Program plans to address these issues and then identify additional ELSI within each domain that warrant ongoing investigation as the All of Us Research Program develops. We conclude that PMI's All of Us Research Program represents a significant opportunity and obligation to identify, analyze, and respond to ELSI, and we call on the PMI to initiate a research program capable of taking on these challenges.Genet Med advance online publication 01 December 2016.
Indexed as
Identifiers
27929525What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.