Evidence map›Paper›PMID 27929469›Full record

ArticleJournal of visualized experiments : JoVE2016

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia.

Andrea Bonetto, Joseph E Rupert, Rafael Barreto, Teresa A Zimmers

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 110 citations in OpenAlex.

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  12. Systemic administration ofJournal for immunotherapy of cancer · 2025
    Article
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  14. Alpha-Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models.Journal of cachexia, sarcopenia and muscle · 2025
    Article
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  17. GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrea BonettoDepartment of Surgery, Simon Cancer Center and IUPUI Center for Cachexia Research, Innovation and Therapy, Indiana University School of Medicine.
Joseph E RupertDepartment of Surgery, Simon Cancer Center and IUPUI Center for Cachexia Research, Innovation and Therapy, Indiana University School of Medicine.
Rafael BarretoDepartment of Surgery, Simon Cancer Center and IUPUI Center for Cachexia Research, Innovation and Therapy, Indiana University School of Medicine.
Teresa A ZimmersDepartment of Surgery, Simon Cancer Center and IUPUI Center for Cachexia Research, Innovation and Therapy, Indiana University School of Medicine; zimmerst@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Manipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaR01CA122596 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZIMMERS, TERESA A · 2010 to 2015
$1.6M
PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4M
(PQB-3) Roles of skeletal muscle mass in chemotherapy-associated cachexiaR21CA190028 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BONETTO, ANDREA · 2014 to 2015
$373k
NCI NIH HHS R01 CA122596NCI NIH HHS R01 CA194593NCI NIH HHS R21 CA190028
6 · The paper itself

Abstract

Cancer cachexia is the progressive loss of skeletal muscle mass and adipose tissue, negative nitrogen balance, anorexia, fatigue, inflammation, and activation of lipolysis and proteolysis systems. Cancer patients with cachexia benefit less from anti-neoplastic therapies and show increased mortality

Indexed as

Colonic NeoplasmsDisease Models, AnimalAnimalsCachexiaCell Line, TumorHumansInterleukin-6MiceMuscle, SkeletalMuscular AtrophyReproducibility of ResultsInterleukin-6

Identifiers

PMID27929469
PMCPMC5226332
OpenAlexW2557277725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.