ArticleeLife2016
Flexible theta sequence compression mediated via phase precessing interneurons.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Hippocampal phase precession may be generated by chimera dynamics.Frontiers in neural circuits · 2025Article
- Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics.The Journal of physiology · 2023Article
- Hippocampal Sequencing Mechanisms Are Disrupted in a Maternal Immune Activation Model of Schizophrenia Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Synaptic learning rules for sequence learning.eLife · 2021Article
- Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies.Neuron · 2020Article
- Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.Cell · 2020Article
- Hippocampal Sequences During Exploration: Mechanisms and Functions.Frontiers in cellular neuroscience · 2019Review
- Synaptic integrative mechanisms for spatial cognition.Nature neuroscience · 2017Review
- Combining Theory, Model, and Experiment to Explain How Intrinsic Theta Rhythms Are Generated in aneNeuroArticle
- Efficient phase coding in hippocampal place cells.Physical review researchArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Encoding of behavioral episodes as spike sequences during hippocampal theta oscillations provides a neural substrate for computations on events extended across time and space. However, the mechanisms underlying the numerous and diverse experimentally observed properties of theta sequences remain poorly understood. Here we account for theta sequences using a novel model constrained by the septo-hippocampal circuitry. We show that when spontaneously active interneurons integrate spatial signals and theta frequency pacemaker inputs, they generate phase precessing action potentials that can coordinate theta sequences in place cell populations. We reveal novel constraints on sequence generation, predict cellular properties and neural dynamics that characterize sequence compression, identify circuit organization principles for high capacity sequential representation, and show that theta sequences can be used as substrates for association of conditioned stimuli with recent and upcoming events. Our results suggest mechanisms for flexible sequence compression that are suited to associative learning across an animal's lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.