ArticleeLife2016
Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 77 citations in OpenAlex.
- TRACR: an anterograde transneuronal tracing system for genetic access across synapses and longitudinal circuit analysis.bioRxiv : the preprint server for biology · 2026Article
- NMDA receptor kinetics drive distinct routes to chaotic firing in pyramidal neurons.Frontiers in computational neuroscience · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.Cell reports · 2025Article
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways.The Journal of general physiology · 2024Article
- GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells.Nature communications · 2024Article
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.eLife · 2023Article
- Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection.iScience · 2023Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.bioRxiv : the preprint server for biology · 2023Article
- Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.Visual neuroscience · 2023Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
- Donut-like organization of inhibition underlies categorical neural responses in the midbrain.Nature communications · 2022Article
- Gain control by sparse, ultra-slow glycinergic synapses.Cell reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dendrites of starburst amacrine cells (SACs) in the mammalian retina are preferentially activated by motion in the centrifugal direction, a property that is important for generating direction selectivity in direction selective ganglion cells (DSGCs). A candidate mechanism underlying the centrifugal direction selectivity of SAC dendrites is synaptic inhibition onto SACs. Here we disrupted this inhibition by perturbing distinct sets of GABAergic inputs onto SACs - removing either GABA release or GABA receptors from SACs. We found that lateral inhibition onto Off SACs from non-SAC amacrine cells is required for optimal direction selectivity of the Off pathway. In contrast, lateral inhibition onto On SACs is not necessary for direction selectivity of the On pathway when the moving object is on a homogenous background, but is required when the background is noisy. These results demonstrate that distinct sets of inhibitory mechanisms are recruited to generate direction selectivity under different visual conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.