ArticleScientific reports2016
Single Molecular Demonstration of Modulating Charge Inversion of DNA.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Local cation-clamping distorts and softens RNA duplex.Communications biology · 2026Article
- Single-molecule measurements of double-stranded DNA condensation.Biophysical journal · 2025Review
- Dynamic Light Scattering of DNA-Ligand Complexes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Comprehensive Regulation of Liquid-Liquid Phase Separation of Polypeptides.Molecules (Basel, Switzerland) · 2023Article
- Visualization of DNA Damage and Protection by Atomic Force Microscopy in Liquid.International journal of molecular sciences · 2022Article
- DNA-Lysozyme Nanoarchitectonics: Quantitative Investigation on Charge Inversion and Compaction.Polymers · 2022Article
- Article
- Structure-guided DNA-DNA attraction mediated by divalent cations.Nucleic acids research · 2020Article
- The promotion and suppression of DNA charge neutralization by the cosolute ectoine.RSC advances · 2019Article
- Article
- DNA Compaction and Charge Neutralization Regulated by Divalent Ions in very Low pH Solution.Polymers · 2019Article
- DNA Phase Transition in Charge Neutralization and Comformation Induced by Trivalent-Hydrolysed Metal Ions.Polymers · 2018Article
- The Mixing Counterion Effect on DNA Compaction and Charge Neutralization at Low Ionic Strength.Polymers · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Charge inversion of DNA is a counterintuitive phenomenon in which the effective charge of DNA switches its sign from negative to positive in the presence of multivalent counterions. The underlying microscopic mechanism is still controversial whether it is driven by a specific chemical affinity or electrostatic ion correlation. It is well known that DNA shows no charge inversion in normal aqueous solution of trivalent counterions though they can induce the conformational compaction of DNA. However, in the same trivalent counterion condition, we demonstrate for the first time the occurrence of DNA charge inversion by decreasing the dielectric constant of solution to make the electrophoretic mobility of DNA increase from a negative value to a positive value. In contrast, the charge inversion of DNA induced by quadrivalent counterions can be canceled out by increasing the dielectric constant of solution. The physical modulation of DNA effective charge in two ways unambiguously demonstrates that charge inversion of DNA is a predominantly electrostatic phenomenon driven by the existence of a strongly correlated liquid (SCL) of counterions at the DNA surface. This conclusion is also supported by the measurement of condensing and unraveling forces of DNA condensates by single molecular MT.
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