ArticleScientific reports2016
Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 90 citations in OpenAlex.
- FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery.Drug delivery · 2026Article
- Effects of borneol on pharmacokinetics and tissue distribution of tetramethylpyrazine in transdermal patch.Drug delivery and translational research · 2026Article
- Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism.Drug delivery and translational research · 2026Article
- Neratinib-loaded solid lipid nanoparticles in dissolvable microneedles for enhanced transdermal breast cancer therapy.Drug delivery and translational research · 2026Article
- Precision dosing of recombinant vaccinia vaccine via pillar-guided microneedle patch confers SARS-CoV-2 immunity.Scientific reports · 2025Article
- Designing Multifunctional Microneedles in Biomedical Engineering: Materials, Methods, and Applications.International journal of nanomedicine · 2025Review
- Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment.Theranostics · 2025Article
- Microneedles: A Versatile Drug Delivery Carrier for Phytobioactive Compounds as a Therapeutic Modulator for Targeting Mitochondrial Dysfunction in the Management of Neurodegenerative Diseases.Current neuropharmacology · 2024Review
- Dissolving and Swelling Hydrogel-Based Microneedles: An Overview of Their Materials, Fabrication, Characterization Methods, and Challenges.Gels (Basel, Switzerland) · 2023Review
- Aspirin microcrystals deposited on high-density microneedle tips for the preparation of soluble polymer microneedles.Drug delivery and translational research · 2023Article
- Article
- Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications.Pharmaceutics · 2023Review
- Potential of Microneedle Systems for COVID-19 Vaccination: Current Trends and Challenges.Pharmaceutics · 2022Review
- Levothyroxine sodium loaded dissolving microneedle arrays for transdermal delivery.ADMET & DMPK · 2022Article
- Advances of Microneedles in Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Finite Element Analysis for Biodegradable Dissolving Microneedle Materials on Skin Puncture and Mechanical Performance Evaluation.Polymers · 2021Article
- Interfacial Area Transport Equation for Bubble Coalescence and Breakup: Developments and Comparisons.Entropy (Basel, Switzerland) · 2021Review
- Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges.Pharmaceutics · 2021Review
- Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics.Journal of clinical medicine · 2021Review
- Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles.Polymers · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug loaded dissolving microneedles (DMNs) fabricated with water soluble polymers have received increasing attentions as a safe and efficient transdermal drug delivery system. Usually, to reach a high drug delivery efficiency, an ideal drug distribution is gathering more drugs in the tip or the top part of DMNs. In this work, we introduce an easy and new method to introduce a bubble with controlled size into the body of DMNs. The introduction of bubbles can prevent the drug diffusion into the whole body of the MNs. The heights of the bubbles are well controlled from 75 μm to 400 μm just by changing the mass concentrations of polymer casting solution from 30 wt% to 10 wt%. The drug-loaded bubble MNs show reliable mechanical properties and successful insertion into the skins. For the MNs prepared from 15 wt% PVA solution, bubble MNs achieve over 80% of drug delivery efficiency in 20 seconds, which is only 10% for the traditional solid MNs. Additionally, the bubble microstructures in the MNs are also demonstrated to be consistent and identical regardless the extension of MN arrays. These scalable bubble MNs may be a promising carrier for the transdermal delivery of various pharmaceuticals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.