ArticleScientific reports2016
Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Sodium Salicylate as Feed Additive in Broilers: Absence of Toxicopathological Findings.Animals : an open access journal from MDPI · 2023Article
- Estimation of silent phenotypes of calf antibiotic dysbiosis.Scientific reports · 2023Article
- Optimizing tylosin dosage for co-infection ofFrontiers in pharmacology · 2023Article
- Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse Model to Study Microbiome Function.mSystems · 2022Article
- Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition.mSystems · 2022Article
- Possible role of the gut microbiota in the pathogenesis of anorexia nervosa.BioPsychoSocial medicine · 2021Review
- The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer.Frontiers in molecular biosciences · 2021Article
- Effect of antibiotic treatment on microbial composition and expression of antimicrobial peptides and cytokines in the chick cecum.Poultry science · 2020Article
- Tetracycline ResistantMicroorganisms · 2019Article
- Corticosterone-mediated physiological stress modulates hepatic lipid metabolism, metabolite profiles, and systemic responses in chickens.Scientific reports · 2019Article
- Effect of fosfomycin,Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling.Scientific reports · 2018Article
- Removal of the cecum affects intestinal fermentation, enteric bacterial community structure, and acute colitis in mice.Gut microbes · 2018Article
- Polymer-spray mass spectrometric detection and quantitation of hydrophilic compounds and some narcotics.Rapid communications in mass spectrometry : RCM · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics can promote growth in livestock (antimicrobial growth promoters, AGPs), however lack of knowledge regarding mechanisms has hampered the development of effective non-antibiotic alternatives. Antibiotics affect eukaryotic cells at therapeutic concentrations, yet effects of AGPs on host physiology are relatively understudied, partially due to the complexity of host-microorganism interactions within the gastrointestinal tract. To determine the direct effects of AGPs on the host, we generated Altered Schaedler Flora (ASF) mice, and administered chlortetracycline (CTC) and tylosin phosphate (TYL) in feed. Mice were challenged with Citrobacter rodentium to determine how AGPs alter host responses to physiological stress. Although CTC and TYL had inconsistent effects on the ASF taxa, AGPs protected mice from weight loss following C. rodentium inoculation. Mice treated with either CTC or TYL had lower expression of βd1 and Il17a in the intestine and had a robust induction of Il17a and Il10. Furthermore, AGP administration resulted in a lower hepatic expression of acute phase proteins (Saa1, Hp, and Cp) in liver tissue, and ameliorated C. rodentium-induced reductions in the expression of genes involved in lipogenesis (Hmgcl and Fabp1). Collectively, this indicates that AGPs directly affect host physiology, and highlights important considerations in the development of non-antibiotic alternatives.
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