ArticleMolecular ecology2017
Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Geographical Distribution of Carnivore Hosts and Genotypes of Canine Distemper Virus (CDV) Worldwide: A Scoping Review and Spatial Meta-Analysis.Transboundary and emerging diseases · 2025Pooled it
- Circulation of arctic canine distemper virus in diarrheic dogs in Iran: molecular detection and phylogenetic characterization.BMC research notes · 2026Article
- Molecular characterisation and histopathological analysis of canine distemper virus in a Malayan tiger (Journal of veterinary science · 2026Article
- Understanding Climate Change Threats to Vertebrate Wildlife by Studying Ecoimmunology Across Biological Scales.Integrative and comparative biology · 2025Review
- Characterization of the Hemagglutinin Gene ofVeterinary sciences · 2025Article
- Global Phylogenetic Analysis of the CDV Hemagglutinin Gene Reveals Positive Selection on Key Receptor-Binding Sites.Viruses · 2025Article
- Mucosal immune responses and intestinal microbiome associations in wild spotted hyenas (Crocuta crocuta).Communications biology · 2025Article
- Detection of canine distemper virus in wildlife in Italy (2022-2024).Frontiers in veterinary science · 2025Article
- Emergence of a Novel Canine Distemper Virus Variant in Urbanized Free-Ranging Marmosets (Transboundary and emerging diseases · 2025Article
- Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication.Communications biology · 2024Article
- Article
- Phylogenetic characterization of canine distemper virus from stray dogs in Kathmandu Valley.Virology journal · 2023Article
- Identification of a new polymorphism on the wild-type canine distemper virus genome: could this contribute to vaccine failures?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Biomolecular Analysis of Canine Distemper Virus Strains in Two Domestic Ferrets (Veterinary sciences · 2023Article
- Detection of Selected Canine Viruses in Nigerian Free-Ranging Dogs Traded for Meat Consumption.Animals : an open access journal from MDPI · 2023Article
- Detection and sequence analysis of Canine morbillivirus in multiple species of the Mustelidae family.BMC veterinary research · 2022Article
- Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany.Scientific reports · 2022Article
- Article
- Complete genomic sequencing of canine distemper virus with nanopore technology during an epizootic event.Scientific reports · 2022Article
- The First Case ofAnimals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Was the 1993/1994 fatal canine distemper virus (CDV) epidemic in lions and spotted hyaenas in the Serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? We examine this question using sequence data from 13 'Serengeti' strains including five complete genomes obtained between 1993 and 2011. Phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other than to those from domestic or wild canids. All noncanid 'Serengeti' strains during the epidemic encoded: (1) one novel substitution G134S in the CDV-V protein; and (2) the rare amino acid combination 519I/549H at two sites under positive selection in the region of the CDV-H protein that binds to SLAM (CD 150) host cell receptors. Worldwide, only a few noncanid strains in the America II lineage encode CDV-H 519I/549H. All canid 'Serengeti' strains during the epidemic coded CDV-V 134G, and CDV-H 519R/549Y, or 519R/549H. A functional assay of cell entry revealed the highest performance by CDV-H proteins encoding 519I/549H in cells expressing lion SLAM receptors, and the highest performance by proteins encoding 519R/549Y, typical of dog strains worldwide, in cells expressing dog SLAM receptors. Our findings are consistent with an epidemic in lions and hyaenas caused by CDV variants better adapted to noncanids than canids, but not with the recent spillover of a dog strain. Our study reveals a greater complexity of CDV molecular epidemiology in multihost environments than previously thought.
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