ArticleJournal of experimental orthopaedics2016
Anatomical study: comparing the human, sheep and pig knee meniscus.
Article in Journal of experimental orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 77 citations in OpenAlex.
- Safety and Efficacy of a Novel Polyglycolic Acid Meniscal Scaffold for Irreparable Meniscal Tear.Cartilage · 2024Trial
- Effects of Preservation on the Compressive Properties and Microstructure of the Knee Meniscus.Annals of biomedical engineering · 2026Article
- Effect of knee flexion angle on the direction and magnitude of tensile force in complete lateral meniscus radial tears: A porcine biomechanical study.Journal of experimental orthopaedics · 2025Article
- Transtibial repair of medial meniscus posterior root tears: Interference screw fixation improves primary stability in a porcine model.Journal of experimental orthopaedics · 2025Article
- Evaluating the Turkey as a novel model for arthroscopic knee surgery research: a comparative analysis with canine and rabbit.BMC musculoskeletal disorders · 2025Article
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- Double-loop suture repair of radial meniscal tears provides favourable biomechanical performance compared to conventional repair techniques: A biomechanical study.Journal of experimental orthopaedics · 2025Article
- A new preclinical sheep model of medial meniscus anterior root repair: Part 1-Quantitative morphology and relationships to adjacent structures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research.Arthritis research & therapy · 2025Review
- Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis.Journal of orthopaedic translation · 2025Review
- Animal models used in meniscal repair research fromJournal of orthopaedics · 2024Review
- Effects of various load magnitudes on ACL: an in vitro study using adolescent porcine stifle joints.Journal of orthopaedic surgery and research · 2024Article
- Usefulness of Probing Sensor Device for Evaluating Meniscal Suture and Scaffold Implantation.Biomimetics (Basel, Switzerland) · 2024Article
- Immunohistochemical Analysis of Knee Chondral Defect Repair after Autologous Particulated Cartilage and Platelet-Rich Plasma Treatment in Sheep.International journal of molecular sciences · 2023Article
- Particulate cartilage and platelet-rich plasma treatment for knee chondral defects in sheep.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Regenerative Effect of Mesenchymal Stem Cell on Cartilage Damage in a Porcine Model.Biomedicines · 2023Article
- Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair.Advanced healthcare materials · 2022Article
- Proteomic, mechanical, and biochemical characterization of cartilage development.Acta biomaterialia · 2022Article
- Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models.Frontiers in cell and developmental biology · 2022Review
- Yucatan Minipig Knee Meniscus Regional Biomechanics and Biochemical Structure Support its Suitability as a Large Animal Model for Translational Research.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnimal models are commonly used in investigating new treatment options for knee joint injuries including injuries to the meniscus. The reliability and applicability of these models to replicate findings in humans depends on determining the most suitable animal proxy. Therefore, this study was designed to compare the wet weight, volume and dimensions of the human meniscus with two commonly used animal models: sheep and pig.
methodsHuman menisci (n = 6 pairs) were obtained from the knee joints of cadaveric male donors. Sheep menisci (n = 6 pairs) and pig menisci (n = 22 pairs) were obtained from the stifle joints of adult sheep and pigs. Meniscal wet weight, volume and dimensions of the body were measured and compared among the species. Anatomical dimensions included circumference, width, peripheral height, articular height and superior articular length.
resultsThe circumference of human menisci (lateral: 84.0 mm, medial: 88.7 mm) was significantly longer than that of sheep (lateral: 50.0 mm, medial: 55.5 mm) and pig (lateral: 66.8 mm, medial: 64.9 mm). The majority of the remaining dimensions of the medial and all of the remaining dimensions of the lateral menisci in sheep showed no statistical difference in comparison to the human menisci. The meniscal weight in pig was significantly larger (lateral: 6.4 g, medial: 5.0 g) than the human (lateral: 4.9 g, medial: 4.4 g) and sheep (lateral: 2.5 g, medial: 2.2 g). Porcine meniscal volume (lateral: 6.5 ml, medial: 5.1 ml) was also larger than the human (lateral: 5.0 ml, medial: 4.5 ml) and sheep (lateral: 2.3 ml, medial: 2.2 ml) menisci. The dimensions measured in the pig meniscus were generally larger than human menisci with statistically significant differences in most categories.
conclusionSheep meniscal dimensions more closely matched human meniscal dimensions than the pig meniscal dimensions. This information may help guide the choice of an animal proxy in meniscal research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.