Evidence map›Paper›PMID 27928723›Full record

ArticleLearning & behavior2017

Boosting weakened synapses to treat Alzheimer's disease.

Robert J McDonald, Scott H Deibel

Abstract read
PubMed Publisher
In one paragraph

Article in Learning & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert J McDonaldDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4. r.mcdonald@uleth.ca.
Scott H DeibelDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper highlights a recent report by Roy and colleagues showing that boosting plasticity in synapses activated during initial memory encoding ameliorates memory impairments found in the early stages of the familial version of Alzheimer's disease. Our goal was to describe the main features of the report and evaluate the approach and implications of the work.

Indexed as

Alzheimer DiseaseAnimalsMemoryMemory DisordersSynapsesAlzheimer’s diseaseEngramGeneticsMemoryPlasticity

Identifiers

PMID27928723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.