Evidence map›Paper›PMID 27928711›Full record

Trial reportInternational urology and nephrology2017

Dry weight assessment by combined ultrasound and bioimpedance monitoring in low cardiovascular risk hemodialysis patients: a randomized controlled trial.

Dimitrie Siriopol, Mihai Onofriescu, Luminita Voroneanu, Mugurel Apetrii, Ionut Nistor, Simona Hogas, Mehmet Kanbay, Radu Sascau, Dragos Scripcariu, Adrian Covic

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Sample Size of Trials Investigating the Impact of Point-of-Care Ultrasound-Guided Strategies on Patient Outcomes: A Systematic Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Review
  13. Volume Assessment in Patients Undergoing Long-Term Dialysis.Journal of the American Society of Nephrology : JASN · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Progress in volume assessment for the hemodialysis patients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dimitrie SiriopolNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Mihai OnofriescuNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Luminita VoroneanuNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Mugurel ApetriiNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Ionut NistorNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Simona HogasNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania.
Mehmet KanbayDivision of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Radu SascauCardiology Department, ''Dr. George IM Georgescu'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, Iasi, Romania.
Dragos ScripcariuGeneral Surgery Department, Regional Institute of Oncology, ''Grigore T. Popa'' University of Medicine and Pharmacy, Iasi, Romania.
Adrian CovicNephrology Department, Dialysis and Renal Transplant Center, ''Dr. C.I. Parhon'' University Hospital, ''Grigore T. Popa'' University of Medicine and Pharmacy, No. 50 Carol I Blvd., Iasi, Romania. accovic@gmail.com.
Grigore T. Popa University of Medicine and Pharmacy · ROKoç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFluid overload is associated with adverse outcomes in hemodialysis (HD) patients. The precise assessment of hydration status in HD patients remains a major challenge for nephrologists. Our study aimed to explore whether combining two bedside methods, lung ultrasonography (LUS) and bioimpedance, may provide complementary information to guide treatment in specific HD patients.

methodsIn total, 250 HD patients from two dialysis units were included in this randomized clinical trial. Patients were randomized 1:1 to have a dry weight assessment based on clinical (control) or LUS with bioimpedance in case of clinical hypovolemia (active)-guided protocol. The primary outcome was to assess the difference between the two groups on a composite of all-cause mortality and first cardiovascular event (CVE)-including death, stroke, and myocardial infarction.

resultsDuring a mean follow-up period was 21.3 ± 5.6 months, there were 54 (21.6%) composite events in the entire population. There was a nonsignificant 9% increase in the risk of this outcome in the active arm (HR = 1.09, 95% CI 0.64-1.86, p = 0.75). Similarly, there were no differences between the two groups when analyzing separately the all-cause mortality and CVE outcomes. However, patients in the active arm had a 19% lower relative risk of pre-dialytic dyspnea (rate ratio-0.81, 95% CI 0.68-0.96), but a 26% higher relative risk of intradialytic cramps (rate ratio-1.26, 95% CI 1.16-1.37).

conclusionsThis study shows that a LUS-bioimpedance-guided dry weight adjustment protocol, as compared to clinical evaluation, does not reduce all-cause mortality and/or CVE in HD patients. A fluid management protocol based on bioimpedance with LUS on indication might be a better strategy.

Indexed as

Body WaterElectric ImpedanceAdultAgedBody CompositionBody WeightCause of DeathFemaleFollow-Up StudiesHemodialysis SolutionsHospitalizationHumansHypotensionKidney Failure, ChronicLungMaleHemodialysis SolutionsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin TBioimpedanceCardiovascular eventsFluid statusHemodialysisLung ultrasonography

Identifiers

PMID27928711
OpenAlexW2560020658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.