Evidence map›Paper›PMID 27928646›Full record

ArticlePharmaceutical research2017

Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles.

Ghobad Mohammadi, Amineh Shakeri, Ali Fattahi, Pardis Mohammadi, Ali Mikaeili, Alireza Aliabadi, Khosro Adibkia

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Nanotools for Sepsis Diagnosis and Treatment.Advanced healthcare materials · 2021
    Review
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ghobad MohammadiNovel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences,, Kermanshah, Iran. ghobadmohammadi@yahoo.com.
Amineh ShakeriStudent Research Committee, Kermanshah University of Medical Sciences,, Kermanshah, Iran.
Ali FattahiNovel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences,, Kermanshah, Iran.
Pardis MohammadiNovel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences,, Kermanshah, Iran.
Ali MikaeiliFaculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Alireza AliabadiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences,, Kermanshah, Iran.
Khosro AdibkiaFaculty of Pharmacy, Tabriz University of Medical Sciences,, Tabriz, Iran.
Kermanshah University of Medical Sciences · IRTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNystatin loaded PLGA and PLGA-Glucosamine nanoparticles were formulated. PLGA were functionalized with Glucosamine (PLGA-GlcN) to enhance the adhesion of nanoparticles to Candida Albicans (C.albicans) cell walls.

methodQuasi-emulsion solvent diffusion method was employed using PLGA and PLGA-GlcN with various drug-polymer ratios for the preparation of nanoparticles. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency and release properties. DSC, SEM, XRPD,

resultsThe spectra of

conclusionPLGA-GlcN nanoparticles showed more antifungal activity with appropriate physicochemical properties than pure Nystatin and PLGA nanoparticles.

Indexed as

Antifungal AgentsCandida albicansChemistry, PharmaceuticalDrug CarriersGlucosamineLactic AcidNanoparticlesNystatinParticle SizePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSpectroscopy, Fourier Transform InfraredAntifungal AgentsDrug CarriersGlucosamineLactic AcidNystatinPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerCandida albicansglucosaminenanoparticlesnystatinPLGA

Identifiers

PMID27928646
OpenAlexW2560131105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.