ArticleClinical research in cardiology : official journal of the German Cardiac Society2017
Incidence, laboratory detection and prognostic relevance of hypoxic hepatitis in cardiogenic shock.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00491036 (Randomized Clinical Study of Intraaortic Balloon Pump Use in Cardiogenic Shock Complicating Acute Myocardial Infarction), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Study of Intraaortic Balloon Pump Use in Cardiogenic Shock Complicating Acute Myocardial Infarction
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Mechanical circulatory support with Impella versus intra-aortic balloon pump or medical treatment in cardiogenic shock-a critical appraisal of current data.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Pooled it
- Prevalence and prognostic relevance of abnormal liver function tests in critically ill patients with cardiac arrest.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- Secondary sclerosing cholangitis in patients suffering cardiogenic shock.ESC heart failure · 2025Article
- Hypoxic hepatitis in survivors of cardiac arrest: A systematic review andResuscitation plus · 2024Article
- Cardiogenic Shock: Focus on Non-Cardiac Biomarkers.Current heart failure reports · 2024Review
- Management of cardiogenic shock: state-of-the-art.Intensive care medicine · 2024Review
- [Liver diseases in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- [ECLS shock study-no advantage for venoarterial ECMO in cardiogenic shock].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Management of cardiogenic shock after acute coronary syndromes.BJA education · 2023Review
- Hemodynamic monitoring in cardiogenic shock.Journal of intensive medicine · 2023Review
- Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients.Critical care (London, England) · 2022Review
- Development and validation of a predictive model for in-hospital mortality in patients with sepsis-associated liver injury.Annals of translational medicine · 2022Article
- Circulating Monocyte Chemoattractant Protein-1 in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction Treated with Mild Hypothermia: A Biomarker Substudy of SHOCK-COOL Trial.Journal of cardiovascular development and disease · 2022Article
- Prediction of 30-day mortality in heart failure patients with hypoxic hepatitis: Development and external validation of an interpretable machine learning model.Frontiers in cardiovascular medicine · 2022Article
- Intensive Care Management of the Cardiogenic Shock Patient.US cardiology · 2022Review
- Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?Annals of intensive care · 2021Article
- Development and Validation of a Diagnostic Model to Predict the Risk of Ischemic Liver Injury After Stanford A Aortic Dissection Surgery.Frontiers in cardiovascular medicine · 2021Article
- Prognostic Value of Abnormal Liver Function Tests After Mechanical Thrombectomy for Acute Ischemic Stroke.Frontiers in neurology · 2021Article
- [Hepatic dysfunction in patients with cardiogenic shock].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the improvement of therapeutic options for patients in acute myocardial infarction (AMI), cardiogenic shock (CS) remains a complication with high mortality rates. Organ failure centrally determines the prognosis of these high-risk patients. Aim of the current study was to assess the incidence of hypoxic hepatitis (HH) in CS, its laboratory detection evaluating novel and established biomarkers and to estimate the prognostic relevance of HH in current clinical practice.
methodsIn 172 patients with CS complicating AMI, blood samples were collected at admission and after 1 day as prespecified subanalysis of the intra-aortic balloon pumping IABP-SHOCK II trial. Classic parameters of HH were measured in addition to argininosuccinate synthase 1 and sulfotransferase isoform SULT2A1 was determined as new biomarker using standard enzyme-linked immunosorbent assay kits. All-cause mortality at 30 days was used for outcome assessment.
resultsThe overall mortality rate was 40%. The incidence of HH with an increase of aminotransferase levels to be 20 times above the upper normal level was 18%. Patients with HH had a distinctly higher 30-day mortality rate compared to patients without HH (68 vs. 34%; p < 0.001). After multivariable adjustment aspartate-aminotransferase (ASAT) remained an independent predictor of 30-day mortality together with serum lactate and serum creatinine, while the new biomarkers failed to predict outcome. Comparing different liver markers using receiver operating characteristic analysis, ASAT showed the highest area under the curve for the prediction of outcome.
conclusionsHH occurs frequently in CS and is associated with particular poor outcome. As conventional biomarker, ASAT is the strongest laboratory predictor of outcome. ClinicalTrials.gov Identifier: NCT00491036.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.