ArticleNeurogenesis (Austin, Tex.)2016
Switching the rate and pattern of cell division for neural tube closure.
Article in Neurogenesis (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Imaging developmental cell cycles.Biophysical journal · 2021Review
- p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice.The Journal of nutrition · 2020Article
- Development of the human penis and clitoris.Differentiation; research in biological diversityArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphogenetic movement associated with neural tube closure (NTC) requires both positive and negative regulations of cell proliferation. The dual requirement of cell division control during NTC underscores the importance of the developmental control of cell division. In the chordate ascidian, midline fusions of the neural ectoderm and surface ectoderm (SE) proceed in the posterior-to-anterior direction, followed by a single wave of asynchronous and patterned cell division in SE. Before NTC, SE exhibits synchronous mitoses; disruption of the synchrony causes a failure of NTC. Therefore, NTC is the crucial turning point at which SE switches from synchronous to patterned mitosis. Our recent work discovered that the first sign of patterned cell division in SE appears was an asynchronous S-phase length along the anterior-posterior axis before NTC: the asynchrony of S-phase is offset by the compensatory G2-phase length, thus maintaining the apparent synchrony of cell division. By the loss of compensatory G2 phase, the synchronized cell division harmoniously switches to a patterned cell division at the onset of NTC. Here we review the developmental regulation of rate and pattern of cell division during NTC with emphasis on the switching mechanism identified in our study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.