Evidence map›Paper›PMID 27928512›Full record

ArticleNPJ aging and mechanisms of disease2016

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca

Erez Eitan, Emmette R Hutchison, Krisztina Marosi, James Comotto, Maja Mustapic, Saket M Nigam, Caitlin Suire, Chinmoyee Maharana, Gregory A Jicha, Dong Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ aging and mechanisms of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Erez EitanLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Emmette R HutchisonLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Krisztina MarosiLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
James ComottoLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Maja MustapicLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Saket M NigamLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Caitlin SuireLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Chinmoyee MaharanaLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Gregory A JichaSanders-Brown Center on Aging, and Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40508.
Dong LiuLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Vasiliki MachairakiDepartment of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Dimitrios KapogiannisLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland 21224.; Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205.
National Institute on Aging · USJohns Hopkins University · USUniversity of Kentucky · US

Funding

Studies in Dementia and Neurodegenerative DiseasesZIAAG000975 · NIA · NATIONAL INSTITUTE ON AGING · PI KAPOGIANNIS, DIMITRIOS · 2009 to 2025
$31.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
Cellular And Molecular Pathogenesis Of Alzheimer's DiseaseZIAAG000312 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTSON, MARK · 2009 to 2018
$6.4M
Hormesis/Adaptive Stress Responses and AgingZIAAG000331 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTSON, MARK · 2009 to 2018
$5.0M
Intramural NIH HHS ZIA AG000312NIA NIH HHS P30 AG028383
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs) are small 50-150 nanometer membrane vesicles that have recently been implicated in the prion-like spread of self-aggregating proteins. Here we report that EVs isolated from AD patient CSF and plasma, from the plasma of two AD mouse models, and from the medium of neural cells expressing familial AD presenilin 1 mutations, destabilize neuronal Ca

Indexed as

Alzheimer's diseaseamyloid β-peptideexosomesextracellular vesiclesglutamatemitochondria

Identifiers

PMID27928512
PMCPMC5137253
OpenAlexW2522545878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.