ArticleNeuro-ophthalmology (Aeolus Press)2016
Macular Thickness in Subjective Memory Complaints and Mild Cognitive Impairment: A Non-Invasive Biomarker.
Article in Neuro-ophthalmology (Aeolus Press), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- A systematic survey of advances in retinal imaging modalities for Alzheimer's disease diagnosis.Metabolic brain disease · 2022Pooled it
- Optical Coherence Tomography in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.Ophthalmology · 2019Pooled it
- Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram.Frontiers in aging neuroscience · 2025Article
- Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease: a meta-analysis.Neural regeneration research · 2023Article
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
- Afferent and Efferent Visual Markers of Alzheimer's Disease: A Review and Update in Early Stage Disease.Frontiers in aging neuroscience · 2020Article
- Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Identification of Retinal Biomarkers in Alzheimer's Disease Using Optical Coherence Tomography: Recent Insights, Challenges, and Opportunities.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the main cause of dementia worldwide, which implies an important socioeconomic problem in developed countries. Efforts to find biomarkers to diagnose AD have been intensified, especially, to detect cognitive impairment in its early stages, also known as mild cognitive impairment (MCI). Besides, there are individuals referring memory loss that is unnoticeable in the family environment and presenting normal neuropsychological tests. The former patients are included in a clinical picture that has been recently called subjective memory complaints (SMC). To achieve an early diagnosis, optical coherence tomography (OCT) has been used to measure macular thickness in patients diagnosed with MCI (supported by neuropsychological tests) and SMC (not based on neuropsychological battery). Statistically significant differences have been found in the macular thickness of the control group (274.96 ± 17.61 µm) and for both MCI (259.48 ± 22.39 µm) and SMC (261.45 ± 24.26 µm) patients. In the near future, OCT could become a reliable biomarker and a useful tool for AD screening as well as for the monitoring of the cognitive impairment associated with AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.