ArticleScience translational medicine2016
Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Continuous extracorporeal hyperoxygenation therapy reduces carbon monoxide half-life time in a carbon monoxide-poisoned pig model: a feasibility study.Scientific reports · 2026Article
- Immobilized neuroglobin scavenges carbon monoxide from circulating carboxyhemoglobin.bioRxiv : the preprint server for biology · 2026Article
- Cytochrome bFree radical biology & medicine · 2026Article
- CytochromebioRxiv : the preprint server for biology · 2025Article
- CO Complexation by Ru(II) and Os(II) Porphyrin Complexes Sheds Light on the Relative Importance of Thermodynamic Stability and Kinetic Lability for CO Poisoning Antidotes.Organometallics · 2025Article
- Inflammatory responses to acute carbon monoxide poisoning and the role of plasma gelsolin.Science advances · 2025Article
- Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system.Scientific reports · 2025Article
- Detoxification of hydrogen sulfide by synthetic heme model compounds.Scientific reports · 2024Article
- Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles.Journal of medicinal chemistry · 2024Review
- Carbon monoxide poisoning and phototherapy.Nitric oxide : biology and chemistry · 2024Review
- Carbon Monoxide Poisoning: From Microbes to Therapeutics.Annual review of medicine · 2024Review
- Artificial porphyrin molecules clean up carbon monoxide and cyanide.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning.JCI insight · 2022Article
- Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.Pharmacological reviews · 2022Review
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
- Kinetic mechanisms for OMolecular aspects of medicine · 2022Review
- Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle.Membranes · 2021Article
- "CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- Emerging cellular-based therapies in carbon monoxide poisoning.American journal of physiology. Cell physiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues. We mutated the distal histidine to glutamine (H64Q) and substituted three surface cysteines with less reactive amino acids to form a five-coordinate heme protein (Ngb-H64Q-CCC). This molecule exhibited an unusually high affinity for gaseous ligands, with a P
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.