ArticleThe Journal of biological chemistry2017
The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis.Biomedicines · 2026Review
- Calmodulin D133H Disrupts CaCells · 2025Article
- Arrhythmogenic calmodulin variants D131E and Q135P disrupt interaction with the L-type voltage-gated CaActa physiologica (Oxford, England) · 2025Article
- Identifying Key Binding Interactions Between the Cardiac L-Type Calcium Channel and Calmodulin Using Molecular Dynamics Simulations.The journal of physical chemistry. B · 2024Article
- Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function.PNAS nexus · 2023Article
- Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket.International journal of molecular sciences · 2023Article
- Long QT syndrome-associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel.The Journal of physiology · 2023Article
- Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State.International journal of molecular sciences · 2023Article
- Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State.bioRxiv : the preprint server for biology · 2023Article
- Role of CaArchives of toxicology · 2023Review
- Calmodulin mutations affecting Gly114 impair binding to the NaFrontiers in pharmacology · 2023Article
- Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte.Biomolecules · 2022Article
- Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias.Cellular and molecular life sciences : CMLS · 2022Article
- CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms.Journal of cell science · 2022Article
- Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors.Frontiers in molecular biosciences · 2022Article
- NaStructure (London, England : 1993) · 2021Article
- The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site.Biochemistry · 2021Article
- Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure.ACS pharmacology & translational science · 2020Review
- The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.The Journal of biological chemistry · 2020Article
- Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Mads Toft SøndergaardFrom the Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0001-6779-5109
Yingjie Liuthe Libin Cardiovascular Institute of Alberta, the Department of Physiology and Pharmacology and the Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Kamilla Taunsig LarsenFrom the Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark.
Alma Nanithe Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612.
Xixi Tianthe Libin Cardiovascular Institute of Alberta, the Department of Physiology and Pharmacology and the Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Christian HoltFrom the Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark.
Ruiwu Wangthe Libin Cardiovascular Institute of Alberta, the Department of Physiology and Pharmacology and the Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Reinhard WimmerFrom the Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0001-6942-5056
Filip Van Petegemthe Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada, and.ORCID 0000-0003-2728-8537
Michael Fillthe Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612.
S R Wayne Chenthe Libin Cardiovascular Institute of Alberta, the Department of Physiology and Pharmacology and the Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 1N4, Canada.ORCID 0000-0001-5808-0304
Michael Toft OvergaardFrom the Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark, mto@bio.aau.dk.ORCID 0000-0002-1423-2481
Aalborg University · DKUniversity of Calgary · CARush University Medical Center · USUniversity of British Columbia · CA
Funding
Limiting Pathological Calcium Induced Calcium Release in HeartR01HL057832 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, GILLESPIE, DIRK · 1997 to 2024
$9.0MSkeletal Muscle Ryanodine Receptor Permeation and Self Counter-Ion FlowR01AR054098 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL · 2007 to 2017
$2.9MControl of IP3R-Mediated Calcium ReleaseR01GM111397 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, SUI RONG WAYNE, FILL, MICHAEL · 2015 to 2018
$1.6MCIHRNHLBI NIH HHS R01 HL057832NIAMS NIH HHS R01 AR054098NIGMS NIH HHS R01 GM111397
Abstract
A number of point mutations in the intracellular Ca
Indexed as
Calcium SignalingMutation, MissenseAmino Acid SubstitutionArrhythmias, CardiacCalciumCalmodulinHEK293 CellsHumansProtein DomainsRyanodine Receptor Calcium Release ChannelCalciumCalmodulinRyanodine Receptor Calcium Release Channelarrhythmiacalcium-binding proteincalcium intracellular releasecalmodulin (CaM)CaM-F142Lcardiac ryanodine receptorprotein-protein interactionryanodine receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.