Evidence map›Paper›PMID 27927938›Full record

Trial reportNeurology2017

Transcranial direct current stimulation for children with perinatal stroke and hemiparesis.

Adam Kirton, Patrick Ciechanski, Ephrem Zewdie, John Andersen, Alberto Nettel-Aguirre, Helen Carlson, Lisa Carsolio, Mia Herrero, Jillian Quigley, Aleksandra Mineyko and 2 more

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02170285 phase2completednot on this map

Enhancing Developmental Motor Plasticity After Perinatal Stroke With Transcranial Direct Current Stimulation

TypeinterventionalSponsorUniversity of CalgaryRan2014 to 2015Enrolled23ConditionsPerinatal Stroke, Cerebral PalsyArmsInterventional TDCS, Sham TDCS
NCT03193580 nacompletednot on this map

Accelerating Motor Learning in Pediatrics

TypeinterventionalSponsorUniversity of CalgaryRan2017 to 2018Enrolled24ConditionsHealthy, PediatricsArmsAnodal Conventional tDCS, Anodal High Definition tDCS, Sham tDCS
NCT03453983 nacompletednot on this mapstarted 2018, after this paper: background citation

Transcranial Direct Current Stimulation (tDCS): A Therapeutic Intervention for Motor Impairments in Children With Developmental Coordination Disorder (DCD).

TypeinterventionalSponsorUniversity of CalgaryRan2018 to 2019Enrolled35ConditionsDevelopmental Coordination DisorderArmsTranscrainial Direct Current Stimulation (tDCS)
NCT03635775 nacompletednot on this mapstarted 2018, after this paper: background citation

Effects of Single-session Transcranial Direct Current Stimulation in Children With Cerebral Palsy

TypeinterventionalSponsorUniversity of MinnesotaRan2018 to 2020Enrolled20ConditionsCerebral Palsy, Perinatal Stroke, Periventricular LeukomalaciaArmsActive tDCS, Sham tDCS
NCT04490187 naunknown statusnot on this mapstarted 2018, after this paper: background citation

tDCS and Motor Learning in Children With DCD

TypeinterventionalSponsorUniversity of British ColumbiaRan2018 to 2021Enrolled14ConditionsDevelopmental Coordination DisorderArmsMotor Learning
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023
    Trial
  6. Trial
  7. Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2018
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Childhood stroke.Nature reviews. Disease primers · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Adam KirtonFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada. adam.kirton@albertahealthservices.ca.
Patrick CiechanskiFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Ephrem ZewdieFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
John AndersenFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Alberto Nettel-AguirreFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Helen CarlsonFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Lisa CarsolioFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Mia HerreroFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Jillian QuigleyFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Aleksandra MineykoFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Jacquie HodgeFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Michael HillFrom the Departments of Pediatrics and Clinical Neurosciences (A.K., A.M.), Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary; Department of Neurosciences (P.C.) and Hotchkiss Brain Institute (A.K., M.H.), Cumming School of Medicine, University of Calgary; Calgary Pediatric Stroke Program (A.K., P.C., E.Z., H.C., A.M., J.H.) and Department of Pediatrics (A.N.-A.), Alberta Children's Hospital; University of Alberta (J.A.), Glenrose Rehabilitation Hospital, Edmonton; and Clinical Neurosciences (L.C., M.H., J.Q.), Alberta Children's Hospital, Alberta Health Services, Calgary, Canada.
Allen Institute for Brain Science · USUniversity of Alberta · CAGlenrose Rehabilitation Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy.

methodsThis was a randomized, controlled, double-blind clinical trial. Participants were recruited from a population-based cohort with MRI-classified unilateral perinatal stroke, age of 6 to 18 years, and disabling hemiparesis. All completed a goal-directed, peer-supported, 2-week after-school motor learning camp (32 hours of therapy). Participants were randomized 1:1 to 1 mA cathodal tDCS over the contralesional primary motor cortex (M1) for the initial 20 minutes of daily therapy or sham. Primary subjective (Canadian Occupational Performance Measure [COPM]), objective (Assisting Hand Assessment [AHA]), safety, and secondary outcomes were measured at 1 week and 2 months after intervention. Analysis was by intention to treat.

resultsTwenty-four participants were randomized (median age 11.8 ± 2.7 years, range 6.7-17.8). COPM performance and satisfaction scores doubled at 1 week with sustained gains at 2 months (p < 0.001). COPM scores increased more with tDCS compared to sham control (p = 0.004). AHA scores demonstrated only mild increases at both time points with no tDCS effects. Procedures were safe and well tolerated with no decrease in either arm function or serious adverse events.

conclusiontDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. CLINICALTRIALSGOV IDENTIFIER: NCT02170285. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA.

Indexed as

AdolescentChildCohort StudiesCombined Modality TherapyCommunity Health PlanningDouble-Blind MethodExercise TherapyFemaleHumansMaleOutcome Assessment, Health CareParesisStrokeStroke RehabilitationTranscranial Direct Current StimulationTreatment Outcome

Identifiers

PMID27927938
OpenAlexW2560681591

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.