ArticleJournal of clinical microbiology2017
Clinical and Microbiological Aspects of β-Lactam Resistance in Staphylococcus lugdunensis.
Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Global prevalence of macrolide-resistantFrontiers in microbiology · 2025Pooled it
- Veterinary method evaluation of Vitek-2 compact for antimicrobial susceptibility testing ofJournal of clinical microbiology · 2026Article
- Clinical presentation, treatment, and antimicrobial susceptibility of 155 sequentialMicrobiology spectrum · 2025Article
- Clinical Significance and Microbiological Characteristics ofJournal of clinical medicine · 2024Article
- Antimicrobial Resistance and Antimicrobial Activity ofMicroorganisms · 2022Article
- Antimicrobial Susceptibility Testing for Staphylococcus lugdunensis.Journal of clinical microbiology · 2022Article
- Comparative Genomic Analyses Reveal Potential Factors Responsible for the ST6 Oxacillin-ResistantFrontiers in microbiology · 2021Article
- Evaluation of penicillin G susceptibility testing methods for Staphylococcus lugdunensis.The Journal of antimicrobial chemotherapy · 2020Article
- Tailoring Antimicrobial Susceptibility Testing to Individual Species of Coagulase-Negative Staphylococci: Next Up, Staphylococcus epidermidis.Journal of clinical microbiology · 2019Article
- Comparative Genome Analysis ofFrontiers in microbiology · 2019Article
- Staphylococcus lugdunensis: a neglected pathogen of infections involving fracture-fixation devices.International orthopaedics · 2017Review
- Article
- Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial susceptibility results from broth microdilution MIC testing of 993 Staphylococcus lugdunensis isolates recovered from patients at a tertiary care medical center from 2008 to 2015 were reviewed. Ninety-two oxacillin-susceptible isolates were selected to assess the accuracy of penicillin MIC testing, the penicillin disk diffusion test, and three β-lactamase tests, including the cefoxitin-induced nitrocefin test, penicillin cloverleaf assay, and penicillin disk zone edge test. The results of all phenotypic tests were compared to the results of blaZ PCR. The medical records of 62 patients from whom S. lugdunensis was isolated, including 31 penicillin-susceptible and 31 penicillin-resistant strains, were retrospectively reviewed to evaluate the clinical significance of S. lugdunensis isolation, the antimicrobial agents prescribed, if any, and the clinical outcome. MIC testing revealed that 517/993 (52.1%) isolates were susceptible to penicillin and 946/993 (95.3%) were susceptible to oxacillin. The induced nitrocefin test was 100% sensitive and specific for the detection of β-lactamase compared to the blaZ PCR results, whereas the penicillin disk zone edge and cloverleaf tests showed sensitivities of 100% but specificities of only 9.1% and 89.1%, respectively. The penicillin MIC test had 100% categorical agreement with blaZ PCR, while penicillin disk diffusion yielded one major error. Only 3/31 patients with penicillin-susceptible isolates were treated with a penicillin family antimicrobial. The majority of cases were treated with other β-lactams, trimethoprim-sulfamethoxazole, or vancomycin. These data indicate that nearly all isolates of S. lugdunensis are susceptible to narrow-spectrum antimicrobial agents. Clinical laboratories in areas with resistance levels similar to those described here can help promote the use of these agents versus vancomycin by effectively designing their antimicrobial susceptibility reports to convey this message.
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Registered trials
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