Evidence map›Paper›PMID 27927913›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.

Amey Dhopeshwarkar, Natalia Murataeva, Alex Makriyannis, Alex Straiker, Ken Mackie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Cannabinoid CBBritish journal of pharmacology · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Cannabinoid CBThe Journal of pharmacology and experimental therapeutics · 2017
    Article
  10. Assessing Allosteric Modulation of CBMethods in enzymology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amey DhopeshwarkarDepartment of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana (A.D., N.M., A.S., K.M.); and Department of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts (A.M.).
Natalia MurataevaDepartment of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana (A.D., N.M., A.S., K.M.); and Department of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts (A.M.).
Alex MakriyannisDepartment of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana (A.D., N.M., A.S., K.M.); and Department of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts (A.M.).
Alex StraikerDepartment of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana (A.D., N.M., A.S., K.M.); and Department of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts (A.M.) straiker@indiana.edu.
Ken MackieDepartment of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana (A.D., N.M., A.S., K.M.); and Department of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts (A.M.).
Northeastern University · USIndiana University Bloomington · US

Funding

Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
Neuronal cannabinoidsR01DA011322 · NIDA · UNIVERSITY OF WASHINGTON · PI MACKIE, KENNETH · 1998 to 2014
$3.4M
Role of CB2 in Analgesic MechanismsR01DA041229 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2016 to 2020
$1.8M
Cannabinoid Modulation of Cell FunctionK05DA021696 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH · 2007 to 2017
$1.3M
Harnessing endogenous cannabinoids for ocular healthR01EY024625 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI STRAIKER, ALEXANDER J · 2014 to 2017
$1.3M
NEI NIH HHS R01 EY024625NIDA NIH HHS K05 DA021696NIDA NIH HHS P01 DA009158NIDA NIH HHS R01 DA011322NIDA NIH HHS R01 DA041229
6 · The paper itself

Abstract

The cannabinoid signaling system includes two G protein-coupled receptors, CB

Indexed as

AnimalsArrestinChromonesColforsinCyclic AMPDose-Response Relationship, DrugEnzyme ActivationHEK293 CellsHippocampusHumansIndolesInositol PhosphatesMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Morpholines1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole3-(1,1-dimethyl-heptyl)-1-hydroxy-9-methoxy-benzo(c)chromen-6-oneArrestinChromonesColforsinCyclic AMPIndolesInositol PhosphatesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MorpholinesPhosphoproteinsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2

Identifiers

PMID27927913
PMCPMC5267514
OpenAlexW2560410148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.