Evidence map›Paper›PMID 27927804›Full record

ReviewPhysiology (Bethesda, Md.)2017

Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.

Anu Sharma, Adrian Vella

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Modeling human disease in rodents by CRISPR/Cas9 genome editing.Mammalian genome : official journal of the International Mammalian Genome Society · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anu SharmaDepartment of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota.
Adrian VellaDepartment of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota.
WinnMed · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
The regulation of fasting glucose metabolism in people with and without prediabetesR01DK078646 · NIDDK · MAYO CLINIC ROCHESTER · PI Adrian Vella · 2007 to 2026
$8.7M
NCATS NIH HHS UL1 TR000135NIDDK NIH HHS R01 DK078646
6 · The paper itself

Abstract

Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

Indexed as

GenotypePhenotypeAnimalsDiabetes Mellitus, Type 2Genetic Association StudiesGenetic Predisposition to DiseaseGlucoseHumansInsulinInsulin SecretionMetabolic DiseasesMiceRisk FactorsGlucoseInsulin

Identifiers

PMID27927804
PMCPMC5338594
OpenAlexW2560755766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.