ArticleJournal of neurophysiology2017
Modeling fast and slow gamma oscillations with interneurons of different subtype.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- Optimal Inhibitory-to-Excitatory Ratio Governs Slow and Fast Oscillations for Enhanced Neural Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Flexible modulation of hybrid feedback loops in competitive biological oscillators.NPJ systems biology and applications · 2025Article
- Delayed Accumulation of Inhibitory Input Explains Gamma Frequency Variation with Changing Contrast in an Inhibition Stabilized Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Encephalography cross-frequency coupling and brain alteration in amyotrophic lateral sclerosis.Brain communications · 2025Article
- Firing rate models for gamma oscillations in I-I and E-I networks.Journal of computational neuroscience · 2024Article
- Fragile X cortex is characterized by decreased parvalbumin-expressing interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Bistability at the onset of neuronal oscillations.Biological cybernetics · 2023Article
- Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.PLoS computational biology · 2023Article
- Regulation of the E/I-balance by the neural matrisome.Frontiers in molecular neuroscience · 2023Review
- Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats.iScience · 2022Article
- Article
- Rhythms of human attention and memory: An embedded process perspective.Frontiers in human neuroscience · 2022Review
- Comprehensive characterization of oscillatory signatures in a model circuit with PV- and SOM-expressing interneurons.Biological cybernetics · 2021Article
- Dentate spikes and external control of hippocampal function.Cell reports · 2021Article
- Article
- Electrophysiology of the Human Superior Temporal Sulcus during Speech Processing.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model.Frontiers in computational neuroscience · 2021Article
- The Generation and Modulation of Distinct Gamma Oscillations with Local, Horizontal, and Feedback Connections in the Primary Visual Cortex: A Model Study on Large-Scale Networks.Neural plasticity · 2021Article
- Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review.Frontiers in synaptic neuroscience · 2021Review
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3 authors.
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Abstract
Experimental and theoretical studies demonstrate that neuronal gamma oscillations crucially depend on interneurons, but current models do not consider the diversity of known interneuron subtypes. Moreover, in CA1 of the hippocampus, experimental evidence indicates the presence of multiple gamma oscillators, two of which may be coordinated by differing interneuron populations. In this article, we show that models of networks with competing interneuron populations with different postsynaptic effects are sufficient to generate, within CA1, distinct oscillatory regimes. We find that strong mutual inhibition between the interneuron populations permits distinct fast and slow gamma states, whereas weak mutual inhibition generates mixed gamma states. We develop idealized firing rate models to illuminate dynamic properties of these competitive gamma networks, and reinforce these concepts with basic spiking models. The models make several explicit predictions about gamma oscillators in CA1. Specifically, interneurons of different subtype phase-lock to different gamma states, and one population of interneurons is silenced and the other active during fast and slow gamma events. Finally, mutual inhibition between interneuron populations is necessary to generate distinct gamma states. Previous experimental studies indicate that fast and slow gamma oscillations reflect different information processing modes, although it is unclear whether these rhythms are intrinsic or imposed. The models outlined demonstrate that basic architectures can locally generate these oscillations, as well as capture other features of fast and slow gamma, including theta-phase preference and spontaneous transitions between gamma states. These models may extend to describe general dynamics in networks with diverse interneuron populations.
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