Evidence map›Paper›PMID 27927780›Full record

SynthesisJournal of the American Society of Nephrology : JASN2017

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis.

Chengguo Wei, Li Li, Madhav C Menon, Weijia Zhang, Jia Fu, Brian Kidd, Karen L Keung, Christopher Woytovich, Ilana Greene, Wenzhen Xiao and 5 more

Open access · bronzeAbstract readMeta-Analysis
In one paragraph

Synthesis in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Multidimensional mechanisms of quercetin in diabetic kidney disease.Frontiers in cell and developmental biology · 2025
    Review
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  13. TGF-β Activity of a Demineralized Bone Matrix.International journal of molecular sciences · 2021
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Chengguo WeiDivisions of *Nephrology and.
Li LiDepartments of Genetics and Genomic Sciences and.
Madhav C MenonDivisions of *Nephrology and.
Weijia ZhangDivisions of *Nephrology and.
Jia FuDivisions of *Nephrology and.
Brian KiddDepartments of Genetics and Genomic Sciences and.
Karen L KeungDepartment of Renal Medicine, Westmead Hospital, Westmead, New South Wales, Australia; and.
Christopher WoytovichDivisions of *Nephrology and.
Ilana GreeneDivisions of *Nephrology and.
Wenzhen XiaoDivisions of *Nephrology and.
Fadi SalemRenal Pathology, and.
Zhengzi YiDivisions of *Nephrology and.
John Cijiang HeDivisions of *Nephrology and cijiang.he@mssm.edu joel.dudley@mssm.edu barbara.murphy@mssm.edu.
Joel T DudleyDepartments of Genetics and Genomic Sciences and cijiang.he@mssm.edu joel.dudley@mssm.edu barbara.murphy@mssm.edu.
Barbara MurphyDivisions of *Nephrology and cijiang.he@mssm.edu joel.dudley@mssm.edu barbara.murphy@mssm.edu.
Icahn School of Medicine at Mount Sinai · USMetabolism and Renal Physiology · FRWestmead Hospital · AU

Funding

VIRAL PATHOGENESIS OF HIV ASSOCIATED NEPHROPATHYP01DK056492 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI HE, JOHN CIJIANG · 1999 to 2021
$27.8M
Genomics of Chronic Renal Allograft RejectionU01AI070107 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2006 to 2012
$9.4M
Role of HIPK2 in Kidney Tubulointerstitial InjuryR01DK088541 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2010 to 2019
$4.0M
Cellular and molecular mechanisms of retinoids in podocytesR01DK078897 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2007 to 2018
$3.6M
An intronic locus determines SHROOM3-expression and potentiates renal allograft fibrosisR01DK102420 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2015 to 2019
$1.9M
User Interface PortalU54CA189201 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUDLEY, JOEL THOMAS, MA'AYAN, AVI · 2014 to 2017
$1.9M
Methods for Evolutionary Informed Network Analysis to Discover Disease VariationR01DK098242 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUDLEY, JOEL THOMAS · 2013 to 2016
$1.7M
NCI NIH HHS U54 CA189201NIAID NIH HHS U01 AI070107NIDDK NIH HHS P01 DK056492NIDDK NIH HHS R01 DK078897NIDDK NIH HHS R01 DK088541NIDDK NIH HHS R01 DK098242NIDDK NIH HHS R01 DK102420
6 · The paper itself

Abstract

Renal fibrosis is the common pathway of progression for patients with CKD and chronic renal allograft injury (CAI), but the underlying mechanisms remain obscure. We performed a meta-analysis in human kidney biopsy specimens with CAI, incorporating data available publicly and from our Genomics of Chronic Renal Allograft Rejection study. We identified an

Indexed as

Kidney TransplantationAnimalsFemaleFibrosisGenomicsHumansKidneyKidney DiseasesMaleMiceMice, Inbred C57BLPostoperative ComplicationsProto-Oncogene Proteins c-hckHck protein, mouseProto-Oncogene Proteins c-hckchronic renal allograft injurydasatinibHckrenal fibrosis

Identifiers

PMID27927780
PMCPMC5407716
OpenAlexW2560629885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.