ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Urinary Incontinence, Incident Parkinsonism, and Parkinson's Disease Pathology in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- The Neuroanatomical Correlates of Bladder Filling: An Activation Likelihood Estimation Meta-Analysis of Functional Neuroimaging Studies.Neurology international · 2025Review
- Association between motor symptom severity and urinary dysfunction in Parkinson's disease: a retrospective study.Frontiers in aging neuroscience · 2025Article
- Urinary Incontinence in a Community-Based Autopsy Cohort Is Associated with Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes.Journal of Alzheimer's disease : JAD · 2023Article
- Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease.Brain pathology (Zurich, Switzerland) · 2018Article
- Comorbidities of community-dwelling older adults with urinary incontinence: A scoping review.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo test the hypothesis that urinary incontinence (UI) is associated with incident parkinsonism in older adults.
methodsWe used data from 2,617 older persons without dementia. Assessment included baseline self-report UI and annual structured exam which assessed parkinsonian signs, motor performances, cognitive function, and self-report disabilities. We used a series of Cox proportional hazards models to examine the association of UI with parkinsonism and adverse health outcomes and a mixed-effect model to examine the association of UI with the annual rate of cognitive decline. In decedents, regression models were used to examine if UI proximate to death was related to postmortem indices of neuropathologies.
resultsAt baseline, more than 45% of participants reported some degree of UI. Over an average of nearly 8 years of follow-up, UI was associated with incident parkinsonism (hazard ratio [HR] = 1.07, 95% CI = 1.02, 1.12), death (HR = 1.07, 95% CI = 1.03, 1.11), incident ADL disability (HR = 1.11, 95% CI = 1.07, 1.16), and incident mobility disability (HR = 1.07, 95% CI = 1.02, 1.13). UI was not related to incident MCI (HR = 1.02, 95% CI = 0.97, 1.07), incident AD dementia (HR = 1.00, 95% CI = 0.95, 1.05) or to the rate of cognitive decline (Estimate = -.002, standard error = .002, p = .167). In 1,024 decedents with brain autopsy, UI proximate to death was related to PD pathology (Lewy body pathology and nigral neuronal loss), but not Alzheimer's disease pathology or other age-related neuropathologies.
conclusionUI in older adults is associated with incident parkinsonism and may identify older adults at risk for accumulating PD brain pathology.
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