Evidence map›Paper›PMID 27927757›Full record

SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies.

Minghui Quan, Pengcheng Xun, Cheng Chen, Ju Wen, Yiyu Wang, Ru Wang, Peijie Chen, Ka He

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. NADScience advances · 2025
    Article
  13. Article
  14. Article
  15. Healthy Behavior for Preventing Cognitive Disability in Older Persons.International journal of environmental research and public health · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minghui QuanDepartment of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.
Pengcheng XunDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
Cheng ChenDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
Ju WenDepartment of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.
Yiyu WangDepartment of Kinesiology and Nutrition, College of Applied Health Science, University of Illinois at Chicago.
Ru WangDepartment of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.
Peijie ChenDepartment of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China. chenpeijie@sus.edu.cn kahe@indiana.edu.
Ka HeDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.

Funding

Trace element levels and risk of strokeR01ES021735 · NIEHS · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA, MCCLURE, LESLIE AIN · 2012 to 2016
$2.3M
NIEHS NIH HHS R01 ES021735
6 · The paper itself

Abstract

backgroundData on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess the association of walking pace with the risk of cognitive decline and dementia among elderly populations.

methodsEligible studies were searched in PubMed and EMBASE through April 22, 2016. Additional information was retrieved through Google Scholar or hand review of the reference lists from the relevant studies. Prospective cohort studies were included if they reported relative risk (RR) and the corresponding 95% confidence interval (CI) of cognitive decline or dementia in relation to walking pace.

resultsSeventeen studies were identified, including 10 studies reporting the RR of cognitive decline (9,949 participants and 2,547 events) and 10 presenting the RR of dementia (14,140 participants and 1,903 events). Comparing the lowest to the highest category of walking pace, the pooled RR was 1.89 (95% CI = 1.54-2.31) for cognitive decline and 1.66 (95% CI = 1.43-1.92) for dementia. With every 1 dm/s (360 m/h) decrement in walking pace, the risk of dementia was increased by 13% (RR = 1.13; 95% CI = 1.08-1.18).

conclusionsThis meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations.

Indexed as

Walking SpeedAgedCognitive DysfunctionCohort StudiesDementiaHumansProspective StudiesRisk AssessmentCognitive declineDementia“Meta-analysis”Walking pace

Identifiers

PMID27927757
PMCPMC5233912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.