ArticleGenome research2017
Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- An AI-guided framework reveals conserved features governing microRNA strand selection.Nucleic acids research · 2026Article
- MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models.Nucleic acids research · 2025Article
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- The Expression of miRNAs Involved in Long-Term Memory Formation in the CNS of the MolluskInternational journal of molecular sciences · 2022Article
- Critical contribution of 3' non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA.Cell reports · 2022Article
- miRNA-Based Regulation of Alternative RNA Splicing in Metazoans.International journal of molecular sciences · 2021Review
- Bombyx mori miR-2845 represses the expression of fibroin light chain gene both in vitro and in vivo.PloS one · 2021Article
- miR-452-5p and miR-215-5p expression levels in colorectal cancer tissues and their relationship with clinicopathological features.Oncology letters · 2020Article
- Evolutionary dynamics of microRNA target sites across vertebrate evolution.PLoS genetics · 2020Article
- Circulating microRNAs as potential biomarkers and therapeutic targets in spinal muscular atrophy.Therapeutic advances in neurological disorders · 2020Review
- Review
- ALG-1 Influences Accurate mRNA Splicing Patterns in theGenetics · 2019Article
- Mechanistic Insights into MicroRNA-Mediated Gene Silencing.Cold Spring Harbor perspectives in biology · 2019Review
- Small noncoding RNA profiles along alternative developmental trajectories in an annual killifish.Scientific reports · 2018Article
- MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution.RNA (New York, N.Y.) · 2018Article
- Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression.RNA (New York, N.Y.) · 2018Article
- An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity.Nucleic acids research · 2018Article
- Article
- A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing.Nucleic acids research · 2017Article
- Designing of RNA Molecule Translating for Activitable Melittin as Selective Targeting ofIranian journal of parasitologyArticle
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Authors and funding
9 authors.
Funding
Abstract
MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA family members possess. Here, we study evolutionary patterns of metazoan miRNAs, focusing on the targeting preferences of the let-7 and miR-10 families. These studies reveal hotspots for sequence evolution with implications for targeting and secondary structure. High-throughput screening for functional targets reveals that each miRNA represses sites with distinct features and regulates a large number of genes with cooperative function in regulatory networks. Unexpectedly, given the high degree of similarity, single-nucleotide changes grant miRNA family members with distinct targeting preferences. Together, our data suggest complex functional relationships among miRNA duplications, novel expression patterns, sequence change, and the acquisition of new targets.
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