Evidence map›Paper›PMID 27927230›Full record

ArticleStem cell research & therapy2016

Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt/β-catenin signaling.

Nadeeka Bandara, Saliya Gurusinghe, Shiang Yong Lim, Haying Chen, Shuangfeng Chen, Dawei Wang, Bryan Hilbert, Le-Xin Wang, Padraig Strappe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Caveolin1: its roles in normal and cancer stem cells.Journal of cancer research and clinical oncology · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Shikonin promotes osteogenesis and suppresses osteoclastogenesis in vitro.American journal of translational research · 2020
    Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nadeeka BandaraSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia.
Saliya GurusingheSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia.
Shiang Yong LimO'Brien Institute Department, St. Vincent's Institute of Medical Research, Fitzroy, VIC, 3065, Australia.
Haying ChenDepartment of Cardiology, Liaocheng People's Hospital and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China.
Shuangfeng ChenDepartment of Cardiology, Liaocheng People's Hospital and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China.
Dawei WangDepartment of Cardiology, Liaocheng People's Hospital and Affiliated Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, 252000, China.
Bryan HilbertSchool of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia.
Le-Xin WangSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia.
Padraig StrappeSchool of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2650, Australia. pstrappe@csu.edu.au.
Liaocheng People's Hospital · CNCharles Sturt University · AUSt Vincents Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is located in a close conformation with the caveolin-1 (CAV-1

methodsNO production was enhanced by lentiviral vector co-delivery of eNOS and CAV-1

resultsNO production as measured by nitrite was significantly increased in eNOS and CAV-1

conclusionsThis study identifies NO as a regulator of canonical Wnt/β-catenin signaling to promote osteogenesis in eASCs which may contribute to novel bone regeneration strategies.

Indexed as

AdipocytesAlkaline PhosphataseAnimalsbeta CateninCalciumCaveolin 1Cell DifferentiationCell LineCells, CulturedCore Binding Factor Alpha 1 SubunitHEK293 CellsHorsesHumansNitric OxideNitric Oxide Synthase Type IIIOsteogenesisAlkaline Phosphatasebeta CateninCalciumCaveolin 1Core Binding Factor Alpha 1 SubunitNitric OxideNitric Oxide Synthase Type III

Identifiers

PMID27927230
PMCPMC5142348
OpenAlexW2560566722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.