ArticleJournal of biomedical science2016
Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.
Article in Journal of biomedical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Smoking, Alcohol Consumption, and Atrial Fibrillation: Mendelian Randomization Study.Cardiovascular toxicology · 2025Article
- Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.International journal of molecular sciences · 2024Article
- The role of aldehyde dehydrogenase 2 in cardiovascular disease.Nature reviews. Cardiology · 2023Review
- Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium.Biomolecules · 2022Article
- Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.Korean circulation journal · 2022Article
- Risk of Incident Atrial Fibrillation in ALDH2-Deficient Variant Carriers: Genetic Predisposition or Habitual Lifestyle?JACC. Asia · 2022Article
- Effect of theJACC. Asia · 2022Article
- Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.Biochimica et biophysica acta. Molecular basis of disease · 2021Article
- Comprehensive analysis of autophagy-related genes and patterns of immune cell infiltration in valvular atrial fibrillation.BMC cardiovascular disorders · 2021Article
- Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.International journal of molecular sciences · 2020Article
- Influence of Different Treatment Strategies on New-Onset Atrial Fibrillation Among Patients With Primary Aldosteronism: A Nationwide Longitudinal Cohort-Based Study.Journal of the American Heart Association · 2020Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians. Here, we examined whether these SNPs were associated with AF in Japanese patients. METHODS AND
resultsFive hundred seventy-seven Japanese patients with AF undergoing catheter ablation and 1935 controls at Hiroshima University Hospital were studied. Alcohol consumption habits, medical history, electrocardiogram (EKG), electrophysiology and cardiac echocardiography were reviewed. Patients were also genotyped for ALDH2 (rs671) and ADH1B (rs1229984). A significant linear correlation was found between ALDH2 genotype and mean alcohol intake (P = 1.7 × 10
conclusionsWhen considering all patients enrolled, the dysfunctional ALDH2 allele was negatively associated with AF. When examining a subset of patients with lone AF, the dysfunctional ALDH2 allele was negatively associated with AF and the slower metabolizing ADH1B allele was positively associated with AF. Hence, prolonged metabolic conversion of alcohol to acetaldehyde may be associated with the occurrence of AF in the Japanese and other East Asian populations.
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