ArticlePharmaceutical biology2017
Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time-kill curve studies.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 117 citations in OpenAlex.
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- Phytochemistry, Antimicrobial, and Antibiofilm Properties of MalagasyPlants (Basel, Switzerland) · 2026Article
- Chemotypic and Seasonal Variations in Essential Oils fromPlants (Basel, Switzerland) · 2025Article
- Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections.Antibiotics (Basel, Switzerland) · 2025Review
- ADME/Tox study and the effect of β-Caryophyllene on the resistant strain ofToxicology reports · 2025Article
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- Exploring the anticancer potential of traditional herbs from Tamil Nadu: a narrative review of ethnomedicinal insights and scientific evidence.Frontiers in immunology · 2025Review
- In Vitro Evaluation of the Antifungal Properties ofLife (Basel, Switzerland) · 2024Article
- Chemical and Biological Properties of Different Romanian Populations of Hyssopus officinalis Correlated via Molecular Docking.Plants (Basel, Switzerland) · 2024Article
- Bioactives of the essential oil from the leaves ofFrontiers in pharmacology · 2024Article
- A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen.Frontiers in pharmacology · 2024Review
- Antibacterial and Analgesic Properties of Beta-Caryophyllene in a Murine Urinary Tract Infection Model.Molecules (Basel, Switzerland) · 2023Article
- Chemical Profiling, Anticholinesterase, Antioxidant, and Antibacterial Potential of the Essential Oil fromAntibiotics (Basel, Switzerland) · 2023Article
- 2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens.Tropical life sciences research · 2023Article
- Phytochemical Composition and Antimicrobial Activity of Essential Oil from the Leaves ofMolecules (Basel, Switzerland) · 2023Article
- Toxicological Effects of Copaiba Oil (Plants (Basel, Switzerland) · 2023Review
- Plant as an Alternative Source of Antifungals againstPlants (Basel, Switzerland) · 2022Review
- Appraisal of selected ethnomedicinal plants as alternative therapies against onychomycosis: Evaluation of synergy and time-kill kinetics.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextOrange Jessamine [Murraya paniculata L. (Rutaceae)] has been used worldwide in folk medicine as an anti-inflammatory, antibiotic and analgesic.
objectiveThe objective of this study is to investigate the in vitro antioxidant, cytotoxic, antibacterial and antifungal activity and the time-kill curve studies of orange jessamine essential oil and β-caryophyllene, as well as the chemical composition of the essential oil. MATERIAL AND
methodsThe cytotoxic activity of M. paniculata and β-caryophyllene (7.8-500 μg/mL) was evaluated using the MTT assay on normal fibroblasts and hepatoma cells. The minimal inhibitory concentration and time-kill curves (24 h) were evaluated against those of Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Enterococcus faecallis, Aspergillus (niger, fumigates and parasiticum) and F. solani by the broth microdilution method. The antioxidant activity was measured by the DPPH and ABTS assays. Chemical composition was evaluated by GC/MS analyses.
resultsGC/MS analyses identified 13 compounds, with β-caryophyllene as the major compound. The oil exhibited moderate antibacterial activity (MIC <1.0 mg/mL) and strong antifungal activity. Time-kill curve studies showed that either the essential oil or β-caryophyllene presented rapid bacterial killing (4 h for S. aureus) and fungicidal effect (2-4 h for F. solani); however, both displayed weak free radical scavenger capacity. The cytotoxic activity exhibited a prominent selective effect against hepatoma cancer cells (IC DISCUSSION AND
conclusionThe experimental data suggest that the activities of M. paniculata essential oil are due to the synergistic action among its components.
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