Evidence map›Paper›PMID 27927057›Full record

ArticlePharmaceutical biology2017

Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability.

Yun Chen, Ling Zeng, Yu Lu, Yulan Yang, Meiyun Xu, Yixuan Wang, Jiaguo Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. First study onVeterinary world · 2023
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  4. Article
  5. Review
  6. Review
  7. Article
  8. Oxidative Stress in Poultry: Lessons from the Viral Infections.Oxidative medicine and cellular longevity · 2018
    Review
  9. Article
  10. Icariin Prevents IL-1Evidence-based complementary and alternative medicine : eCAM · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yun Chena Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Ling Zenga Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Yu Lub National Research Center of Veterinary Biologicals Engineering and Technology, Jiangsu Academy of Agricultural Science , Nanjing , PR China.
Yulan Yanga Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Meiyun Xua Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Yixuan Wanga Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Jiaguo Liua Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , P R China.
Nanjing Agricultural University · CNJiangsu Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextDuck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1) is an acute and lethal disease of young ducklings. However, there is still no effective drug to treat DVH.

objectiveThis study assessed the curative effect on DVH of a flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) as well as the hepatoprotective and antioxidative effects of BLIN. MATERIALS AND

methodsMTT method was used to test the anti-DHAV-1 ability of BLIN in vitro. We then treated ducklings by BLIN (3 mg per duckling, once a day for 5 days) to evaluate the in vivo efficacy. To study the hepatoprotective and antioxidative roles of BLIN in its curative effect on DVH, we investigated the hepatic injury evaluation biomarkers and the oxidative stress evaluation indices of the ducklings.

resultsOn duck embryonic hepatocytes, DHAV-1 inhibitory rate of BLIN at 20 μg/mL was 69.3%. The survival rate of ducklings treated by BLIN was about 35.5%, which was significantly higher than that of virus control (0.0%). After the treatment of BLIN, both the hepatic injury and the oxidative stress of infected ducklings alleviated. At the same time, a significant positive correlation (p < 0.05) existed between the hepatic injury indices and the oxidative stress indices.

conclusionsBLIN showed a significant curative effect on DVH. The antioxidative and hepatoprotective effects of BLIN made great contributions to the treatment of DVH. Furthermore, BLIN is expected to be exploited as a new drug for the clinical treatment of DVH.

Indexed as

DucksAnimalsAnimals, NewbornAntioxidantsAntiviral AgentsBiomarkersCells, CulturedDrug CombinationsFlavonoidsGinsenosidesGlycosidesHepatitis, AnimalHepatitis Virus, DuckHepatocytesLiverOxidative StressAntioxidantsAntiviral AgentsbaicalinBiomarkersDrug CombinationsFlavonoidsGinsenosidesGlycosidesicariinlinarinnotoginsenoside R1antioxidative effectbaicalin-linarin-icariin-notoginsenoside R1Duck hepatitis A virus type 1hepatoprotective ability

Identifiers

PMID27927057
PMCPMC6130485
OpenAlexW2559941452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.