Evidence map›Paper›PMID 27927051›Full record

ArticlePharmaceutical biology2017

Effect of berberine on PPAR

Hongmei Qiu, Yang Wu, Quanhua Wang, Changqing Liu, Lai Xue, Hong Wang, Qin Wu, Qingsong Jiang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Effects of Berberine on Atherosclerosis.Frontiers in pharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hongmei Qiua Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Yang Wua Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Quanhua Wanga Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Changqing Liua Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Lai Xuea Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Hong Wanga Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Qin Wub Department of Pharmacology, Key Laboratory for Basic Pharmacology of Ministry of Education , Zunyi Medical College , Guizhou , P.R. China.
Qingsong Jianga Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology , Chongqing Medical University , Chongqing , P.R. China.
Chongqing Medical University · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe available treatments for the abnormal proliferation of vascular smooth muscle cells (VSMCs) are still dismal. Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs proliferation. Many studies showed that PPARα and NO participated in the process of VSMCs proliferation.

objectiveTo evaluate the effect of berberine and its possible influence on PPARα-NO pathway in angiotensin IV-stimulated VSMCs. MATERIALS AND

methodsThe primary VSMCs were cultured with the tissue explants method, and the proliferation was characterized by MTT and protein content. Protein and mRNA expression were measured by Western blot and real-time RT-PCR, respectively. NO synthase (NOS) activity was measured using a spectrophotometric assay, and NO concentration was measured using the Griess assay.

resultsAngiotensin IV (0.1 nmol/L)-induced VSMCs proliferation was evidenced by increasing the optical density at A DISCUSSION AND

conclusionThe results support the therapeutic effects of berberine on angiotensin IV-induced proliferation in cultured VSMCs at least partially through targeting the PPARα-NO signalling pathway.

Indexed as

Angiotensin IIAnimalsBerberineCell ProliferationCells, CulturedChlorobenzenesDose-Response Relationship, DrugFemaleIndolesMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNitric OxideNitric Oxide Synthase Type IIIPPAR alphaPrimary Cell CultureAngiotensin IIangiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-BerberineChlorobenzenesIndolesMK-886Nitric OxideNitric Oxide Synthase Type IIINos3 protein, ratPPAR alphaRNA, MessengereNOSlNOSPeroxisome proliferator-activated receptor-α

Identifiers

PMID27927051
PMCPMC6130450
OpenAlexW2560149946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.