Evidence map›Paper›PMID 27926996›Full record

ArticleJournal of neurochemistry2017

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

Bitna Yi, James J Sahn, Pooneh Memar Ardestani, Andrew K Evans, Luisa L Scott, Jessica Z Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan T Pierce and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 116 citations in OpenAlex.

  1. Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Trial
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  15. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  16. Article
  17. Article
  18. Highly specific σProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Highly specific σbioRxiv : the preprint server for biology · 2023
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Bitna YiDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
James J SahnDepartment of Chemistry, The University of Texas at Austin, Austin, Texas, USA.
Pooneh Memar ArdestaniDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
Andrew K EvansDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
Luisa L ScottWaggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, Center for Learning and Memory, Center for Brain, Behavior and Evolution and Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Jessica Z ChanDepartment of Chemistry, The University of Texas at Austin, Austin, Texas, USA.
Sangeetha IyerWaggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, Center for Learning and Memory, Center for Brain, Behavior and Evolution and Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Ashley CrispWaggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, Center for Learning and Memory, Center for Brain, Behavior and Evolution and Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Gabriella ZunigaWaggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, Center for Learning and Memory, Center for Brain, Behavior and Evolution and Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Jonathan T PierceWaggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, Center for Learning and Memory, Center for Brain, Behavior and Evolution and Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Stephen F MartinDepartment of Chemistry, The University of Texas at Austin, Austin, Texas, USA.
Mehrdad ShamlooDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
The University of Texas at Austin · USStanford University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2011 to 2019
$6.3M
High-speed opto-fluidics to screen entire nervous system in aging and diseaseR01AG041135 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI BEN-YAKAR, ADELA, PIERCE, JONATHAN THOMAS · 2011 to 2015
$2.8M
NIA NIH HHS R01 AG041135NIH HHS P40 OD010440NINDS NIH HHS P30 NS069375
6 · The paper itself

Abstract

Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R ligands and their cellular and in vivo activity in experimental models of Alzheimer's disease (AD). We report that SAS-0132 and DKR-1051, selective ligands of Sig2R, modulate intracellular Ca

Indexed as

Disease Models, AnimalAlzheimer DiseaseAnimalsCell Line, TumorCognition DisordersDose-Response Relationship, DrugHumansInflammationInflammation MediatorsLigandsMaleMiceMice, Inbred C57BLMice, TransgenicNeuroprotective AgentsProtein BindingInflammation MediatorsLigandsNeuroprotective AgentsReceptors, sigmasigma-2 receptorAlzheimer's diseaseintracellular calciumlearning and memoryneuroprotectionSig2R/PGRMC1

Identifiers

PMID27926996
PMCPMC5312682
OpenAlexW2560084727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.