ArticleCell reports2016
Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin.Science advances · 2026Article
- Article
- Article
- Cluster assembly dynamics drive fidelity of planar cell polarity polarization.Nature communications · 2026Article
- Mathematical modeling of planar cell polarity: principles, approaches, and open questions.NPJ systems biology and applications · 2026Review
- Planar cell polarity emerges through polarized accumulation of Wnt11.Science advances · 2026Article
- Article
- Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polarity.bioRxiv : the preprint server for biology · 2025Article
- Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension.Nature communications · 2025Article
- Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.Nature communications · 2025Article
- Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing.Nature communications · 2025Article
- Structural basis of human VANGL-PRICKLE interaction.Nature communications · 2025Article
- Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1.Nature communications · 2025Article
- Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation.Open biology · 2024Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- A vertebrate Vangl2 translational variant required for planar cell polarity.The Journal of biological chemistry · 2024Article
- Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway.Current biology : CB · 2023Article
- A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.PLoS genetics · 2023Article
- Distinct mechanisms of planar polarization by the core and Fat-Dachsous planar polarity pathways in the Drosophila wing.Cell reports · 2022Article
- Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2.Nature communications · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
In developing epithelia, the core planar polarity proteins physically interact with each other and localize asymmetrically at opposite cell ends, forming intercellular complexes that link the polarity of neighboring cells. Using quantitative imaging to examine the composition of the core protein complex in vivo, we find that complex composition is unexpectedly plastic. The transmembrane proteins Frizzled and Flamingo form a stoichiometric nucleus in the complex, while the relative levels of the other four core proteins can vary independently. Exploring the functional consequences of this, we show that robust cell polarization is achieved over a range of complex stoichiometries but is dependent on maintaining appropriate levels of the components Frizzled and Strabismus. We propose that the core proteins assemble into signalosome-like structures, where stable association is not dependent on one-to-one interactions with binding partners, and signaling functions can act over a wide range of complex compositions.
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