ArticleObstetrics and gynecology2017
Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus.
Article in Obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 189 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Intervention to Improve Glycemic Control in Women With Gestational Diabetes
Association of Hypertensive Disorder of Pregnancy With Sleep-disordered Breathing.
Who cites it
189 citing papers in PubMed, 7 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Effect of the maternal sleep disturbances and obstructive sleep apnea on feto-placental Doppler: A systematic review.Journal of sleep research · 2025Pooled it
- Continuous Positive Airway Pressure Treatment and Hypertensive Adverse Outcomes in Pregnancy: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Maternal sleep disordered breathing and offspring growth outcome: A systematic review and meta-analysis.Sleep medicine reviews · 2024Pooled it
- Polygenic prediction of preeclampsia and gestational hypertension.Nature medicine · 2023Pooled it
- A Systematic Review of Studies Examining Associations between Sleep Characteristics with Dietary Intake and Eating Behaviors during Pregnancy.Nutrients · 2023Pooled it
- Pooled it
- The prevalence of obstructive sleep apnea and its association with pregnancy-related health outcomes: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2019Pooled it
- Association between sleep quality with maternal and neonatal outcomes during the covid-19 pandemic.BMC pregnancy and childbirth · 2024Trial
- Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial.Respiratory research · 2023Trial
- Adherence and efficacy of mandibular advancement splint treatment of sleep-disordered breathing during pregnancy: a pilot study.Sleep & breathing = Schlaf & Atmung · 2023Trial
- Analytical approaches to evaluating hypertensive disorders of pregnancy.American journal of obstetrics & gynecology MFM · 2023Trial
- The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health.American journal of respiratory and critical care medicine · 2022Trial
- Hypertension Management in Pregnancy and Postpartum.Journal of the American Society of Nephrology : JASN · 2026Review
- Questionnaire-Based Assessment of Obstructive Sleep Apnea Risk During Pregnancy: Associations with Metabolic Parameters and Family History of Diabetes.Healthcare (Basel, Switzerland) · 2026Article
- Association Between Maternal Protein Intake and the Risk of Adverse Pregnancy Outcomes.Nutrients · 2026Article
- Subtypes of Hypertension 2 to 7 Years After First Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026Observational
- The implications of maternal sleep disruption on cardiovascular adaptations and cardiometabolic outcomes.The Lancet. Obstetrics, gynaecology, & women's health · 2026Article
- Racial Differences in Adverse Pregnancy Outcomes and Incident Hypertension: A Mediation Analysis.Journal of the American Heart Association · 2026Article
- Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders of pregnancy and gestational diabetes mellitus (GDM).
methodsIn this prospective cohort study, nulliparous women underwent in-home sleep-disordered breathing assessments in early (6-15 weeks of gestation) and midpregnancy (22-31 weeks of gestation). Participants and health care providers were blinded to the sleep test results. An apnea-hypopnea index of 5 or greater was used to define sleep-disordered breathing. Exposure-response relationships were examined, grouping participants into four apnea-hypopnea index groups: 0, greater than 0 to less than 5, 5 to less than 15, and 15 or greater. The study was powered to test the primary hypothesis that sleep-disordered breathing occurring in pregnancy is associated with an increased incidence of preeclampsia. Secondary outcomes were rates of hypertensive disorders of pregnancy, defined as preeclampsia and antepartum gestational hypertension, and GDM. Crude and adjusted odds ratios and 95% confidence intervals (CIs) were calculated from univariate and multivariate logistic regression models.
resultsThree thousand seven hundred five women were enrolled. Apnea-hypopnea index data were available for 3,132 (84.5%) and 2,474 (66.8%) women in early and midpregnancy, respectively. The corresponding prevalence of sleep-disordered breathing was 3.6% and 8.3%. The prevalence of preeclampsia was 6.0%, hypertensive disorders of pregnancy 13.1%, and GDM 4.1%. In early and midpregnancy the adjusted odds ratios for preeclampsia when sleep-disordered breathing was present were 1.94 (95% CI 1.07-3.51) and 1.95 (95% CI 1.18-3.23), respectively; hypertensive disorders of pregnancy 1.46 (95% CI 0.91-2.32) and 1.73 (95% CI 1.19-2.52); and GDM 3.47 (95% CI 1.95-6.19) and 2.79 (95% CI 1.63-4.77). Increasing exposure-response relationships were observed between apnea-hypopnea index and both hypertensive disorders and GDM.
conclusionThere is an independent association between sleep-disordered breathing and preeclampsia, hypertensive disorders of pregnancy, and GDM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.