ArticleObstetrics and gynecology2017
Ovarian Conservation and Overall Survival in Young Women With Early-Stage Cervical Cancer.
Article in Obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Oncological Outcomes and Safety of Ovarian Preservation for Early Stage Adenocarcinoma of Cervix: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Optimizing ovarian dose sparing for young cervical cancer patients after oophoropexy: a dosimetric and radiobiological comparison of three radiotherapy techniques (IMPT, TOMO, and VMAT).Radiation oncology (London, England) · 2026Article
- HPV status as a predictor of ovarian metastasis in cervical adenocarcinoma: implications for surgical decision-making.BMC women's health · 2026Article
- Influence of ovarian-sparing surgery and ovariectomy on prognosis in early cervical adenocarcinoma: a systematic review and meta-analysis.Gland surgery · 2022Article
- Endometrial cancer.Nature reviews. Disease primers · 2021Review
- Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data.International journal of clinical oncology · 2021Article
- Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.Obstetrics and gynecology · 2020Review
- Populational trends and outcomes of postoperative radiotherapy for high-risk early-stage cervical cancer with lymph node metastasis: concurrent chemo-radiotherapy versus radiotherapy alone.American journal of obstetrics and gynecology · 2020Article
- A prognostic model guides surgical resection in cervical squamous cell carcinoma.Translational cancer research · 2020Article
- Ovarian preservation for premenopausal women with early-stage endometrial cancer: a Chinese retrospective study.The Journal of international medical research · 2019Article
- Survival outcomes of different treatment modalities in patients with low-grade endometrial stromal sarcoma.Chinese medical journal · 2019Article
- Validation of the 2018 FIGO cervical cancer staging system.Gynecologic oncology · 2019Article
- Association of tumor differentiation grade and survival of women with squamous cell carcinoma of the uterine cervix.Journal of gynecologic oncology · 2018Observational
- Tumor-specific outcome of metachronous uterine malignancy after pelvic irradiation for cervical cancer.Gynecologic oncology · 2018Article
- Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis.Gynecologic oncology · 2018Article
- Identifying a candidate population for ovarian conservation in young women with clinical stage IB-IIB cervical cancer.International journal of cancer · 2018Article
- Risk of metachronous ovarian cancer after ovarian conservation in young women with stage I cervical cancer.American journal of obstetrics and gynecology · 2017Article
- Ovarian conservation for young women with clinical stage IB-IIB cervical cancer in Japan.Journal of gynecologic oncology · 2017Article
- Significance of uterine corpus tumor invasion in early-stage cervical cancer.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2017Article
- Differences in Cervical Cancer Outcomes by Caribbean Nativity in Black and White Women in Florida.Cancer control : journal of the Moffitt Cancer CenterArticle
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7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify predictors of ovarian conservation at hysterectomy and to examine the association of ovarian conservation and survival of young women with early-stage cervical cancer.
methodsThis is a retrospective cohort study using the Surveillance, Epidemiology, and End Results Program to identify hysterectomy-based surgically treated patients with stage I cervical cancer diagnosed between 1983 and 2012 (N=16,511). Multivariable models were used to identify independent factors associated with ovarian conservation. Among the subgroup of 9,419 women younger than 50 years of age with stage I disease, survival outcomes and causes of death were examined for 3,908 (41.5%) women who underwent ovarian conservation at hysterectomy without radiotherapy.
resultsOn multivariable analysis, age younger than 50 years, stage IA disease, and squamous histology were independent factors associated with ovarian conservation (all, P<.001). Among 5,526 women younger than 50 years of age with stage IA disease who underwent hysterectomy without radiotherapy, overall survival was significantly higher in patients undergoing ovarian conservation than in those undergoing oophorectomy (20-year rate, 93.5% compared with 86.8%, P<.001); cervical cancer-specific survival was similar between the patients who underwent ovarian conservation and those who underwent oophorectomy (98.8% compared with 97.8%, P=.12). On multivariable analysis, ovarian conservation remained an independent prognostic factor for improved overall survival (adjusted hazard ratio 0.63, 95% confidence interval [CI] 0.49-0.82, P=.001) and was independently associated with lower cumulative risks of death resulting from cardiovascular disease (20-year cumulative rate, 1.2% compared with 3.3%, adjusted hazard ratio 0.47, 95% CI 0.26-0.86, P=.014) and other chronic disease (0.5% compared with 1.4%, adjusted hazard ratio 0.24, 95% CI 0.09-0.65, P=.005) compared with oophorectomy. Both cervical cancer-specific survival (20-year rate, 93.1% compared with 92.0%, P=.37) and overall survival (86.7% compared with 84.6%, P=.12) were similar between ovarian conservation and oophorectomy among 3,893 women younger than 50 years of age with stage IB disease who underwent hysterectomy without radiotherapy.
conclusionAmong young women with stage IA cervical cancer, ovarian conservation at hysterectomy is associated with decreased all-cause mortality including death resulting from cardiovascular disease and other chronic diseases.
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