Evidence map›Paper›PMID 27926528›Full record

Trial reportOncotarget2017

Ketamine rapidly relieves acute suicidal ideation in cancer patients: a randomized controlled clinical trial.

Wei Fan, HaiKou Yang, Yong Sun, Jun Zhang, Guangming Li, Ying Zheng, Yi Liu

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 7 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 7 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  10. Trial
  11. Review
  12. Inflammation and treatment strategies for suicidal behavior.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026
    Review
  13. Psychedelic therapy and cultural humility.Translational psychiatry · 2026
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wei FanDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
HaiKou YangDepartment of Anesthesiology, Maternal and Child Health Care Hospital of Huai'an City, Qingpu, Huai'an City, Jiangsu, 223002, P.R. China.
Yong SunDepartment of Burn and Plastic Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
Jun ZhangDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
Guangming LiDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
Ying ZhengDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
Yi LiuDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, Jiangsu, 223300, P.R. China.
Nanjing Medical University · CNHuaian First People’s Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to examine the rapid antidepressant effects of single dose ketamine on suicidal ideation and overall depression level in patients with newly-diagnosed cancer. Forty-two patients were enrolled into the controlled trial and randomized into two groups: ketamine group and midazolam group. Patients from the two groups received a sub-anesthetic dose of racemic ketamine hydrochloride or midazolam. Suicidal ideation score, measured with the Beck Scale and suicidal part of the Montgomery-Asberg Depression Rating Scale, significantly decreased on day 1 and day 3 in ketamine-treated patients when compared to those treated with midazolam. Consistently, overall depression levels measured using the Montgomery-Asberg Depression Rating Scale indicated a significant relief of overall depression on day 1 in ketamine-treated patients. Collectively, this study provides novel information about the rapid antidepressant effect of ketamine on acute depression and suicidal ideation in newly-diagnosed cancer patients.

Indexed as

Suicidal IdeationAdultAntidepressive AgentsDepressionFemaleHumansKetamineMaleMidazolamMiddle AgedNeoplasmsTime FactorsTreatment OutcomeAntidepressive AgentsKetamineMidazolamcancerdepressionketaminesuicidal ideation

Identifiers

PMID27926528
PMCPMC5356805
OpenAlexW2559576040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.