Evidence map›Paper›PMID 27926498›Full record

SynthesisOncotarget2017

Prognostic value of RDW in cancers: a systematic review and meta-analysis.

Linhui Hu, Manman Li, Yangyang Ding, Lianfang Pu, Jun Liu, Jingxin Xie, Michael Cabanero, Jingrong Li, Ru Xiang, Shudao Xiong

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04860115 (Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery), which is not on this map. Cited by 120 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04860115 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery

TypeinterventionalSponsorSt. Elizabeth Cancer Institute, SlovakiaRan2021 to 2023Enrolled120ConditionsInflammatory MarkersArmsModified pectoralis block (PEC II) and pecto-intercostal fascial plane block (PIFB)
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Uncovering prognostic biomarkers through a pharmacovigilance study: the case of RDW.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linhui HuDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Manman LiDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Yangyang DingDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Lianfang PuDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Jun LiuDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Jingxin XieDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
Michael CabaneroUniversity Health Network, University of Toronto, Ontario, Canada.
Jingrong LiDepartment of Emergency, The Second Hospital of Anhui Medical university, Hefei, Anhui, People's Republic of China.
Ru XiangSchool of Nursing, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Shudao XiongDepartment of Hematology/Hematological Laboratory, The Second Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we performed a meta-analysis and systematic review to evaluate the prognostic value of RDW in cancer patients. Relevant studies were picked out from the databases of Web of Science, Embase, Pubmed and Cochrane Library. A total of 16 papers with 4267 patients were included in this meta-analysis, and the combined results indicated that elevated RDW was associated with poor over survival (OS) (HR = 1.47, 95%CI:1.29-1.66), poor cancer-specific survival (CSS) (HR = 1.46, 95%CI:1.08-1.85), poor disease-free survival (DFS) (HR = 1.91, 95%CI:1.27-2.56), poor event-free survival (EFS) (HR = 2.98, 95%CI:0.57-5.39) and poor progress-free survival (PFS) (HR = 3.21, 95%CI:0.33-6.75) after treatment. Furthermore, the similar results were observed in subgroup analysis stratified by cancer type, cutoff value of RDW, sample size and ethnicity. In conclusion, this meta-analysis demonstrated that RDW may be a potential prognostic marker in patients with cancer, and high RDW may also be associated with poor outcomes.

Indexed as

Erythrocyte IndicesHumansNeoplasmsPrognosiscancermeta-analysisprognosisred blood cell distribution width

Identifiers

PMID27926498
PMCPMC5362543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.