ArticleHuman vaccines & immunotherapeutics2017
Costs associated with influenza-related hospitalization in the elderly.
Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- High Clinical Burden of Influenza Disease in Adults Aged ≥ 65 Years: Can We Do Better? A Systematic Literature Review.Advances in therapy · 2023Pooled it
- Influenza Vaccination in Spain: Understanding the Impact of Suboptimal Coverage on Health, Society, and the Economy.Vaccines · 2026Review
- Combating respiratory diseases with mucosal vaccines.Journal of virology · 2026Review
- Uptake of Influenza Vaccine among Older Adults with Cardiovascular Comorbidities.Arquivos brasileiros de cardiologia · 2025Article
- How Does the Burden of Respiratory Syncytial Virus Compare to Influenza in Spanish Adults?Influenza and other respiratory viruses · 2024Article
- A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness.PLoS pathogens · 2022Article
- [Influenza and cardiorespiratory events: a clinical-epidemiological review with a multidisciplinary point of view].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Review
- Seasonal Influenza and Low Flu Vaccination Coverage as Important Factors Modifying the Costs and Availability of Hospital Services in Poland: A Retrospective Comparative Study.International journal of environmental research and public health · 2021Article
- Incidence and costs of hospitalized adult influenza patients in The Netherlands: a retrospective observational study.The European journal of health economics : HEPAC : health economics in prevention and care · 2020Observational
- Hospital and economic burden of influenza-like illness and lower respiratory tract infection in adults ≥50 years-old.BMC health services research · 2019Article
- Influenza vaccination coverage in the elderly and socio-economic inequalities in Italy.Journal of preventive medicine and hygiene · 2018Article
- Underdiagnosis of Influenza Virus Infection in Hospitalized Older Adults.Journal of the American Geriatrics Society · 2018Article
- Estimating the burden of seasonal influenza in Spain from surveillance of mild and severe influenza disease, 2010-2016.Influenza and other respiratory viruses · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seasonal influenza epidemics remain a considerable burden in adults, especially in those at higher risk of complications. The aim of this study was to determine the costs associated with influenza-related hospitalization in patients aged ≥65 y admitted to 20 hospitals from 7 Spanish regions during the 2013-14 and 2014-15 influenza seasons. Bivariate analysis was used to compare costs in vaccinated and unvaccinated cases. Costs were calculated according to the Spanish National Health System diagnosis-related group tables for influenza and other respiratory system conditions (GRD 89 and GRD 101). A total of 728 confirmed influenza cases were recorded: 52.9% were male, 46.7% were aged 75-84 years, and 49.3% received influenza vaccine ≥15 d prior to hospital admission. Influenza-related mean hospitalization costs (MHC) were € 1,184,808 in unvaccinated and € 1,152,333 in vaccinated cases (2.75% lower). Influenza vaccination showed significant protection against ICU admission (OR 0.35, 95%CI 0.21-0.59; p < 0001); mechanical ventilation (OR 0.56, 95%CI 0.39-0.80; p = 0.002); secondary bacterial pneumonia (OR 0.61, 95%CI 0.39-0.98; p = 0.04) and a higher degree of dependence (OR 0.74, 95%CI 0.55-0.99; p = 0.04). No association was observed for the Charlson comorbidity index or the mean hospital stay. Although influenza vaccination of the elderly may not achieve significant savings in mean hospitalization costs, it may lessen the degree of severity and avoid complications.
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