ArticlePharmaceutical biology2017
Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- LC-ESI-MS/MS-based molecular networking, antioxidant, anti-glioma activity and molecular docking studies of Clematis graveolens.Plant methods · 2024Article
- Cytotoxicity of alkaloids isolated from Peganum harmala seeds on HCT116 human colon cancer cells.Molecular biology reports · 2024Article
- Chemical Profile and Healthy Properties of SicilianMolecules (Basel, Switzerland) · 2024Article
- Review
- Volatile composition, antidiabetic, and anti-obesity potential ofPharmaceutical biology · 2022Article
- A MajorPlants (Basel, Switzerland) · 2022Article
- Evaluating the Impact of Thermal Processing on the Anti-Inflammatory Activity of Non-Centrifugal Cane Sugar: Implications on Cytokine Secretion and TLR4 Signaling.Frontiers in pharmacology · 2022Article
- Composition and Antioxidant Activity of Phenolic Compounds in Fruit of the GenusAntioxidants (Basel, Switzerland) · 2021Article
- Review
- Therapeutic Opportunities and Challenges in Targeting the Orphan G Protein-Coupled Receptor GPR35.ACS pharmacology & translational science · 2020Review
- A computational study on the reaction between fisetin and 2,2-diphenyl-1-picrylhydrazyl (DPPH).Journal of molecular modeling · 2019Article
- Evaluation of the antioxidant potential of myricetin 3-O-α-L-rhamnopyranoside and myricetin 4Journal of molecular modeling · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectiveDiplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is overactivated and represents an interesting therapeutic target. Several flavonoids can inhibit GSK3β and the purpose of this study was to search for the compounds in Diplotaxis harra which are able to modulate GSK3β. MATERIALS AND
methodsMethanol extracts from D. harra flowers were prepared and the bio-guided fractionation of their active compounds was performed using inflammatory [protease-activated receptor 2 (PAR
resultsThe methanol extract from D. harra flowers and its flavonoid-enriched fraction inhibit GSK3β in PAR
conclusionThis work indicates that flavonoids from D. harra display cytotoxic activity against inflammatory and cancer intestinal cells which could depend on GSK3β inhibition.
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