Trial reportThe British journal of radiology2017
A prospective evaluation of contrast and radiation dose and image quality in cardiac CT in children with complex congenital heart disease using low-concentration iodinated contrast agent and low tube voltage and current.
Trial report in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Feasibility of reducing the contrast dose in infants and children with complex congenital heart disease using virtual monoenergetic images on dual-layer spectral detector computed tomography.Pediatric radiology · 2026Trial
- Pediatric Cardiac Imaging With Second- and Third-generation Dual Source CT Scanners: Radiation Dose, and Diagnostic Accuracy in Comparison With Echocardiography and MRI-A Systematic Review and Meta-analysis.Journal of the Saudi Heart Association · 2026Review
- Long-Term Coronary Artery Evaluation Using Noncontrast-Enhanced Magnetic Resonance Angiography in Patients with Kawasaki Disease.Pediatric cardiology · 2026Article
- Weight-based flow rate triphasic contrast injection protocol for pediatric cardiac computed tomography.Quantitative imaging in medicine and surgery · 2025Article
- Artificial intelligence-driven diagnosis of acute thoracic aortic dissection: integrating imaging, biomarkers, and clinical workflows-a narrative review.Annals of translational medicine · 2025Review
- Effectiveness of the air-gap method for reducing radiation dose in neonate CT examinations.Radiological physics and technology · 2025Article
- Artificial intelligence-powered solutions for automated aortic diameter measurement in computed tomography: a narrative review.Annals of translational medicine · 2024Review
- Correlation of patient characteristics with peak enhancement time for pediatric cardiac computed tomography in congenital heart disease.Journal of clinical imaging science · 2024Article
- Clinical Question Influence on Radiation Dose of Cardiac CT Scan in Children.Children (Basel, Switzerland) · 2022Article
- Preoperative Morphological Prediction of Early Reoperation Risk After Primary Repair in Tetralogy of Fallot: A Contemporary Analysis of 83 Cases.Pediatric cardiology · 2021Article
- Chest CTA in children younger than two years - a retrospective comparison of three contrast injection protocols.Scientific reports · 2019Article
- Catheter, MRI and CT Imaging in Newborns with Pulmonary Atresia with Ventricular Septal Defect and Aortopulmonary Collaterals: Quantifying the Risks of Radiation Dose and Anaesthetic Time.Pediatric cardiology · 2018Article
- Recent advances in cardiac computed tomography dose reduction strategies: a review of scientific evidence and technical developments.Journal of medical imaging (Bellingham, Wash.) · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo the assess image quality, contrast dose and radiation dose in cardiac CT in children with congenital heart disease (CHD) using low-concentration iodinated contrast agent and low tube voltage and current in comparison with standard dose protocol.
methods110 patients with CHD were randomized to 1 of the 2 scan protocols: Group A (n = 45) with 120 mA tube current and contrast agent of 270 mgI/ml in concentration (Visipaque
resultsThere was no difference in age and weight between the two groups (all p > 0.05). The iodine load and radiation dose in Group A were statistically lower (3976 ± 747 mgI vs 5763 ± 1018 mgI in iodine load and 0.60 ± 0.08 mSv vs 0.77 ± 0.10 mSv in effective dose; p < 0.001). However, image noise, CT value, CNR, SNR and subjective image quality for the two groups were similar (all p > 0.05), and with good agreement between the two observers. Comparing the surgery results, the diagnostic accuracy for extracardiac and intracardiac defects for Group A was 96% and 92%, respectively, while the corresponding numbers for Group B were 95% and 93%.
conclusionCompared with the standard dose protocol, the use of low tube voltage (80 kVp), low tube current (120 mA) and low-concentration iodinated contrast agent (270 mgI/ml) enables a reduction of 30% in iodine load and 22% in radiation dose while maintaining compatible image quality and diagnostic accuracy. Advances in knowledge: The new cardiac CT scanning protocol can largely reduce the adverse effects of radiation and contrast media to children. Meanwhile, it also can be used effectively to examine complex CHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.