Trial reportThe Journal of physiology2017
Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans.
Trial report in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Effect of transcranial direct current stimulation for patients with disorders of consciousness: A systematic review and meta-analysis.Frontiers in neuroscience · 2022Pooled it
- When brain stimulation backfires: the effects of prefrontal cortex stimulation on impulsivity.Social cognitive and affective neuroscience · 2022Trial
- Transcranial direct current stimulation leads to faster acquisition of motor skills, but effects are not maintained at retention.PloS one · 2022Trial
- Deep Transcranial Magnetic Stimulation Affects Gut Microbiota Composition in Obesity: Results of Randomized Clinical Trial.International journal of molecular sciences · 2021Trial
- Expanding the parameter space of anodal transcranial direct current stimulation of the primary motor cortex.Scientific reports · 2019Trial
- Hypericum perforatum extract modulates cortical plasticity in humans.Psychopharmacology · 2018Trial
- Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans.The international journal of neuropsychopharmacology · 2017Trial
- Modulating cortical excitability and cortical arousal by pupil self-regulation.Nature communications · 2025Article
- Gating of Neuroplasticity: Effects and Mechanisms of Acute Aerobic Exercise as a Brain Stimulation for the Sensorimotor Cortex.Advances in neurobiology · 2025Review
- Review
- Recovery of consciousness after acute brain injury: a narrative review.Journal of intensive care · 2024Review
- Transcranial Direct Current Stimulation to Ameliorate Post-Stroke Cognitive Impairment.Brain sciences · 2024Review
- Modal Analysis of Cerebrovascular Effects for Digital Health Integration of Neurostimulation Therapies-A Review of Technology Concepts.Brain sciences · 2024Article
- Neuron type-specific optogenetic stimulation for differential stroke recovery in chronic capsular infarct.Experimental & molecular medicine · 2024Article
- Neuromodulation in psychiatry: State-of-the-art & future directions.Asian journal of psychiatry · 2024Article
- Impact of Transcranial Direct Current Stimulation in Pain, Fatigue, and Health Quality of Life of Patients with Idiopathic Inflammatory Myopathies: A Randomized, Double-Blind, Sham-Controlled Crossover Clinical Trial.International journal of rheumatology · 2024Article
- Individual Differences in Decision Strategy Relate to Neurochemical Excitability and Cortical Thickness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reinterpreting published tDCS results in terms of a cranial and cervical nerve co-stimulation mechanism.Frontiers in human neuroscience · 2023Article
- Assessing the Effect of Simultaneous Combining of Transcranial Direct Current Stimulation and Transcutaneous Auricular Vagus Nerve Stimulation on the Improvement of Working Memory Performance in Healthy Individuals.Frontiers in neuroscience · 2022Article
- Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans.The international journal of neuropsychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsChronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases. ABSTRACT: Noradrenaline affects cognition and motor learning processes via its impact on long-term potentiation (LTP) and depression (LTD). We aimed to explore the impact of single dose and chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) on plasticity induced by transcranial direct current stimulation (tDCS) in healthy humans via a double-blinded, placebo-controlled, randomized crossover study. Sixteen healthy volunteers received placebo or single dose RBX (8 mg) before anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took RBX (8 mg day
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.