Evidence map›Paper›PMID 27925203›Full record

ArticleThe Journal of pathology2017

The genetic landscape of breast carcinomas with neuroendocrine differentiation.

Caterina Marchiò, Felipe C Geyer, Charlotte Ky Ng, Salvatore Piscuoglio, Maria R De Filippo, Marco Cupo, Anne M Schultheis, Raymond S Lim, Kathleen A Burke, Elena Guerini-Rocco and 5 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Neuroendocrine neoplasms of the breast: a review of literature.Virchows Archiv : an international journal of pathology · 2024
    Review
  10. Article
  11. Nonlobular Invasive Breast Carcinomas with Biallelic Pathogenic CDH1 Somatic Alterations: A Histologic, Immunophenotypic, and Genomic Characterization.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  16. Article
  17. Article
  18. The classification of neuroendocrine neoplasms of the breast and its clinical relevance.Virchows Archiv : an international journal of pathology · 2022
    Review
  19. Clinical and genomic analyses of neuroendocrine neoplasms of the breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 4 countries.

Caterina MarchiòDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Felipe C GeyerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Charlotte Ky NgDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Salvatore PiscuoglioDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria R De FilippoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marco CupoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Anne M SchultheisDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Raymond S LimDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kathleen A BurkeDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Elena Guerini-RoccoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mauro PapottiDepartment of Oncology, University of Turin, Turin, Italy.
Larry NortonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anna SapinoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jorge S Reis-FilhoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USUniversity of Turin · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Neuroendocrine breast carcinomas (NBCs) account for 2-5% of all invasive breast cancers, and are histologically similar to neuroendocrine tumours from other sites. They typically express oestrogen receptor (ER), and are HER2-negative and of luminal 'intrinsic' subtype. Here, we sought to define the mutational profile of NBCs, and to investigate whether NBCs and common forms of luminal (ER

Indexed as

Gene Expression Regulation, NeoplasticBiomarkers, TumorBreast NeoplasmsCarcinoma, LobularCarcinoma, NeuroendocrineClass I Phosphatidylinositol 3-KinasesFemaleHumansMutationPhosphatidylinositol 3-KinasesReceptors, EstrogenBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesPIK3CA protein, humanReceptors, Estrogenbreast carcinomachromogranin Acopy number alterationsmassively parallel sequencingneuroendocrine differentiationsomatic mutationssynaptophysin

Identifiers

PMID27925203
PMCPMC5481202
OpenAlexW2563442973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.